HGNC ID: 18731
Target Abstract:
Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) in humans is a protein encoded by the PDCD1LG2 gene. The gene is located on chromosome 9, p24.2. PD-L2 is one of two programmed death ligands (PD-1) and is a member of the CD28 family of immunoreceptors. Widely expressed PD-L2 was detected by Northern blot analysis and was highest in the placenta, heart, pancreas, lungs, and liver, and lower in the spleen, lymph nodes, and thymus.PD-L2 counter-regulates T cells and has an important role in immune tolerance. At sites of inflammation, PD-L2 upregulated synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. Furthermore, in macrophages and alveolar epithelial cells PD-L2 binds RGM-B thus supporting respiratory immune tolerance.
PDCD1LG2 Target Infomation Overview
- Target Symbol: PDCD1LG2, programmed cell death 1 ligand 2
- Gene Groups: CD molecules; Receptor ligands; Immunoglobulin like domain containing; B7 family
- Alias: PD-L2; Btdc; PDL2; bA574F11.2; CD273; B7-DC
- Alias Names: B7 dendritic cell molecule
PDCD1LG2, programmed cell death 1 ligand 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human PDCD1LG2 Target Information
- Target Symbol: PDCD1LG2, programmed cell death 1 ligand 2
- Alias:
- B7 dendritic cell molecule
- B7-DC
- B7DC
- bA574F11.2
- Btdc
- butyrophilin B7-DC
- CD273
- MGC142238
- MGC142240
- PD-1 ligand 2
- PD-1-ligand 2
- PD-L2
- PDCD1 ligand 2
- PDCD1L2
- PDL2
- programmed death ligand 2
- NCBI_Gene: 80380
- UniProtKB: Q9BQ51
Human PDCD1LG2 Predicted Functions
Involved in negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; and negative regulation of interleukin-10 production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis.
Mouse Pdcd1lg2 Target Information
- Target Symbol: Pdcd1lg2, programmed cell death 1 ligand 2
- Alias:
- B7-DC
- Btdc
- F730015O22Rik
- PD-L2
- RIKEN cDNA F730015O22 gene
- NCBI_Gene: 58205
Mouse Pdcd1lg2 Predicted Functions
Acts upstream of or within negative regulation of T cell proliferation and positive regulation of T cell proliferation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system epithelium; forebrain; nose; retina; and skin. Orthologous to human PDCD1LG2 (programmed cell death 1 ligand 2).
Rat Pdcd1lg2 Target Information
- Target Symbol: Pdcd1lg2, programmed cell death 1 ligand 2
- Alias:
- LOC309304
- PD-1 ligand 2
- PD-L2
- PDCD1 ligand 2
- programmed death ligand 2
- NCBI_Gene: 309304
- UniProtKB: D4AAV6
Rat Pdcd1lg2 Predicted Functions
Predicted to be involved in several processes, including cellular response to lipopolysaccharide; negative regulation of cytokine production; and regulation of T cell activation. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Orthologous to human PDCD1LG2 (programmed cell death 1 ligand 2).
