HGNC ID: 11909
Target Abstract:
Osteoprotectin (OPG), also known as osteoclast inhibitory factor (OCIF) or tumor necrosis factor receptor superfamily member 11B(TNFRSF11B), is a cytokine receptor that is a member of the tumor necrosis factor receptor superfamily. OPG reduces the production of osteoclasts by inhibiting the differentiation of osteoclast precursors into osteoclasts, and also regulates the absorption of osteoclasts in vitro and in vivo. Recombinant human OPG acts specifically on bone and can increase bone mineral density and volume. Elevated OPG levels have been reported in patients with heart disease and severe mental disorders. In recent years, researchers have speculated that OPG may have a link between bone and cardiovascular disease, specifically associated with increased cardiovascular risk in people with diabetes.
TNFRSF11B Target Infomation Overview
- Target Symbol: TNFRSF11B, TNF receptor superfamily member 11b
- Gene Groups: Tumor necrosis factor receptor superfamily
- Alias: OCIF; TR1
- Previous Names: OPG
- Alias Names: osteoclastogenesis inhibitory factor; osteoprotegerin; tumor necrosis factor receptor superfamily, member 11b
TNFRSF11B, TNF receptor superfamily member 11b Target Infomation by Species
- Human
- Mouse
- Rat
Human TNFRSF11B Target Information
- Target Symbol: TNFRSF11B, TNF receptor superfamily member 11b
- Alias:
- MGC29565
- OCIF
- OPG
- osteoclastogenesis inhibitory factor
- osteoprotegerin
- Paget disease of bone 5
- PDB5
- TR1
- tumor necrosis factor receptor superfamily member 11B
- tumor necrosis factor receptor superfamily, member 11b
- NCBI_Gene: 4982
- UniProtKB: O00300
Human TNFRSF11B Predicted Functions
Predicted to enable cytokine activity and signaling receptor activity. Predicted to be involved in skeletal system development. Predicted to act upstream of or within extracellular matrix organization and negative regulation of odontogenesis of dentin-containing tooth. Located in extracellular space. Implicated in Paget’s disease of bone and osteoarthritis. Biomarker of several diseases, including artery disease (multiple); end stage renal disease; hereditary arterial and articular multiple calcification syndrome; lupus nephritis; and type 2 diabetes mellitus.
Mouse Tnfrsf11b Target Information
- Target Symbol: Tnfrsf11b, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
- Alias:
- OCIF
- OPG
- Opg
- osteoclastogenesis inhibitory factor
- osteoprotegerin
- TR1
- NCBI_Gene: 18383
Mouse Tnfrsf11b Predicted Functions
Acts upstream of or within extracellular matrix organization and negative regulation of odontogenesis of dentin-containing tooth. Located in extracellular matrix. Is expressed in several structures, including arterial system; bone; gut; lung; and placenta. Used to study osteoporosis. Human ortholog(s) of this gene implicated in Paget’s disease of bone and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b).
Rat Tnfrsf11b Target Information
- Target Symbol: Tnfrsf11b, TNF receptor superfamily member 11B
- Alias:
- MGC93568
- Opg
- Osteoprotegerin
- tumor necrosis factor receptor superfamily member 11B
- tumor necrosis factor receptor superfamily, member 11b
- tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
- NCBI_Gene: 25341
- UniProtKB: O08727
Rat Tnfrsf11b Predicted Functions
Predicted to enable cytokine activity. Involved in several processes, including negative regulation of bone resorption; negative regulation of odontogenesis of dentin-containing tooth; and response to estrogen. Located in extracellular space. Biomarker of congestive heart failure; myocarditis; and periapical periodontitis. Human ortholog(s) of this gene implicated in Paget’s disease of bone and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b).
