HGNC ID: 2195
Target Abstract:
Endostatin is a 20 kDa protein fragment derived from the non-collagenous (NC1) domain of type XVIII collagen. It is an endogenous inhibitor of angiogenesis, specifically inhibiting endothelial cell proliferation and blood vessel formation. Initially identified as a factor produced by murine endothelioma cells, endostatin plays a crucial role in wound healing by inhibiting tumor growth and impairing vascular maturation. It is involved in endothelial cell adhesion and cytoskeletal organization. Endostatin may also contribute to downregulating angiogenesis in physiological processes such as wound healing and establishment of placental circulation. The anti-angiogenic activity of endostatin is attributed to its ability to inhibit endothelial cell proliferation and suppress VEGF and FGF-induced endothelial cell migration and adhesion. Many of these effects are thought to be mediated by interactions between endostatin and transglutaminase 2 expressed on endothelial cells, heparin, and integrins α5β1 and αVβ3.
COL18A1 Target Infomation Overview
- Target Symbol: COL18A1, collagen type XVIII alpha 1 chain
- Gene Groups: Collagens; MicroRNA protein coding host genes
- Alias: KS; KNO1
- Previous Names: KNO
- Alias Names: endostatin; Knobloch syndrome, type 1; collagen, type XVIII, alpha 1
COL18A1, collagen type XVIII alpha 1 chain Target Infomation by Species
- Human
- Mouse
- Rat
Human COL18A1 Target Information
- Target Symbol: COL18A1, collagen type XVIII alpha 1 chain
- Alias:
- antiangiogenic agent
- collagen alpha-1(XVIII) chain
- collagen alpha-1(XVIII) chain isoform 1 preproprotein
- collagen type XVIII alpha 1
- collagen, type XVIII, alpha 1
- endostatin
- FLJ27325
- FLJ34914
- GLCC
- KNO
- KNO1
- Knobloch syndrome
- KS
- MGC74745
- multi-functional protein MFP
- NCBI_Gene: 80781
- UniProtKB: P39060
Human COL18A1 Predicted Functions
Enables identical protein binding activity. Predicted to be involved in angiogenesis; endothelial cell morphogenesis; and extracellular matrix organization. Predicted to act upstream of or within positive regulation of cell migration; positive regulation of cell population proliferation; and positive regulation of endothelial cell apoptotic process. Located in extracellular exosome. Colocalizes with collagen-containing extracellular matrix. Implicated in primary angle-closure glaucoma.
Mouse Col18a1 Target Information
- Target Symbol: Col18a1, collagen, type XVIII, alpha 1
- Alias:
- endostatin
- NCBI_Gene: 12822
Mouse Col18a1 Predicted Functions
Predicted to enable identical protein binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within several processes, including angiogenesis; endothelial cell morphogenesis; and positive regulation of endothelial cell apoptotic process. Located in basement membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study pigment dispersion syndrome. Human ortholog(s) of this gene implicated in primary angle-closure glaucoma. Orthologous to human COL18A1 (collagen type XVIII alpha 1 chain).
Rat Col18a1 Target Information
- Target Symbol: Col18a1, collagen type XVIII alpha 1 chain
- Alias:
- collagen alpha-1(XVIII) chain
- collagen type XVIII alpha 1
- collagen, type XVIII, alpha 1
- procollagen, type XVIII, alpha 1
- NCBI_Gene: 85251
Rat Col18a1 Predicted Functions
Predicted to enable identical protein binding activity. Predicted to be an extracellular matrix structural constituent. Involved in response to hydrostatic pressure and response to xenobiotic stimulus. Located in extracellular space. Used to study hepatocellular carcinoma. Biomarker of gastric ulcer and ulcerative colitis. Human ortholog(s) of this gene implicated in primary angle-closure glaucoma. Orthologous to human COL18A1 (collagen type XVIII alpha 1 chain).
