HGNC ID: 3430
Target Abstract:
ErbB2 is encoded by the ERBB2 gene in humans, commonly referred to as the oncogene human epidermal growth factor receptor 2 (HER2) or CD340. HER2 is composed of three parts: extracellular ligand binding domain, transmembrane domain, and intracellular domain. These domains can interact with a large number of signaling molecules, demonstrating ligand dependent and non ligand dependent activity. Amplification or overexpression of the oncogene plays an important role in the development of some undesirable types of breast cancer. In recent years, this protein has become an important target of biological therapy for nearly 30% of breast cancer patients.
ERBB2 Target Infomation Overview
- Target Symbol: ERBB2, erb-b2 receptor tyrosine kinase 2
- Gene Groups: CD molecules; Minor histocompatibility antigens; Erb-b2 receptor tyrosine kinases; MicroRNA protein coding host genes
- Alias: NEU; HER-2; CD340; HER2
- Previous Names: NGL
- Alias Names: neuro/glioblastoma derived oncogene homolog; human epidermal growth factor receptor 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
ERBB2, erb-b2 receptor tyrosine kinase 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human ERBB2 Target Information
- Target Symbol: ERBB2, erb-b2 receptor tyrosine kinase 2
- Alias:
- c-erb B2/neu protein
- CD340
- HER-2
- HER-2/neu
- HER2
- herstatin
- human epidermal growth factor receptor 2
- metastatic lymph node gene 19 protein
- MLN 19
- NEU
- neuro/glioblastoma derived oncogene homolog
- neuroblastoma/glioblastoma derived oncogene homolog
- NGL
- p185erbB2
- proto-oncogene c-ErbB-2
- proto-oncogene Neu
- receptor tyrosine-protein kinase erbB-2
- TKR1
- tyrosine kinase-type cell surface receptor HER2
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
- v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- VSCN2
- NCBI_Gene: 2064
- UniProtKB: P04626
Human ERBB2 Predicted Functions
Enables several functions, including ErbB-3 class receptor binding activity; enzyme binding activity; and protein C-terminus binding activity. Contributes to growth factor binding activity. Involved in several processes, including positive regulation of macromolecule biosynthetic process; protein phosphorylation; and regulation of MAPK cascade. Acts upstream of or within cell surface receptor signaling pathway. Located in several cellular components, including basolateral plasma membrane; cytosol; and endosome membrane. Part of ERBB3:ERBB2 complex. Implicated in carcinoma (multiple); high grade glioma; reproductive organ cancer (multiple); and urinary bladder cancer. Biomarker of several diseases, including carcinoma (multiple); ductal carcinoma in situ; invasive lobular carcinoma; pre-eclampsia (multiple); and urinary system cancer (multiple).
Mouse Erbb2 Target Information
- Target Symbol: Erbb2, erb-b2 receptor tyrosine kinase 2
- Alias:
- avian erythroblastosis oncogene B 2
- c-erbB2
- c-neu
- Erbb-2
- ErbB-2
- HER-2
- HER2
- l11Jus8
- lethal, Chr 11, Justice 8
- mKIAA3023
- Neu
- Neu oncogene
- NCBI_Gene: 13866
Mouse Erbb2 Predicted Functions
Predicted to enable several functions, including ErbB-3 class receptor binding activity; Hsp90 protein binding activity; and enzyme binding activity. Predicted to contribute to growth factor binding activity. Involved in positive regulation of GTPase activity and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including negative regulation of immature T cell proliferation in thymus; nervous system development; and neuromuscular junction development. Located in apical plasma membrane; cytoplasmic vesicle; and myelin sheath. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and sensory organ. Used to study Hirschsprung’s disease; breast cancer; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); high grade glioma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2).
Rat Erbb2 Target Information
- Target Symbol: Erbb2, erb-b2 receptor tyrosine kinase 2
- Alias:
- Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)
- C-erbB-2
- epidermal growth factor receptor-related protein
- HER2/neu
- LOC102552659
- neu
- NEU proto-oncogene
- p185erbB2
- p185neu
- proto-oncogene c-ErbB-2
- proto-oncogene NEU
- receptor tyrosine-protein kinase erbB-2
- receptor tyrosine-protein kinase erbB-2-like
- v-erb-b2 avian erythroblastic leukemia viral oncogene 2
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- NCBI_Gene: 24337
Rat Erbb2 Predicted Functions
Enables Hsp90 protein binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of intracellular signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral loop; and microvillus. Biomarker of congestive heart failure and median neuropathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2).
