HGNC ID: 10638
Target Abstract:
C-X-C motif chemokine 11 (CXCL11), also known as interferon-induced T-cell alpha chemokine (I-TAC), is a small molecule cytokine in the CXC chemokine family. Its gene is located on human chromosome 4, as are many other members of the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas, and liver, moderately expressed in thymus, spleen, and lung, and poorly expressed in small intestine, placenta, and prostate tissues.CXCL11 gene expression is strongly induced by IFN-γ and IFN-β, and weakly by IFN-α. CXCL11 acts on target cells by interacting with CXCR3, a cell surface chemokine receptor. CXCL11 converges activated T cells.CXCL11 has angiogenic inhibitory effects and is involved in allergic contact dermatitis, atherosclerosis, mycosis fungoides (a type of T-cell lymphoma), and immune-mediated disorders of the central nervous system such as multiple sclerosis.CXCL11 has been shown to inhibit the expression of the CXCL11 gene, whereas IFN-α is less inducible.
CXCL11 Target Infomation Overview
- Target Symbol: CXCL11, C-X-C motif chemokine ligand 11
- Gene Groups: Chemokine ligands
- Alias: H174; b-R1; I-TAC; IP-9
- Previous Names: SCYB9B; SCYB11
- Alias Names: small inducible cytokine subfamily B (Cys-X-Cys), member 11; chemokine (C-X-C motif) ligand 11
CXCL11, C-X-C motif chemokine ligand 11 Target Infomation by Species
- Human
- Mouse
- Rat
Human CXCL11 Target Information
- Target Symbol: CXCL11, C-X-C motif chemokine ligand 11
- Alias:
- b-R1
- beta-R1
- C-X-C motif chemokine 11
- chemokine (C-X-C motif) ligand 11
- H174
- I-TAC
- interferon gamma-inducible protein 9
- interferon-inducible T-cell alpha chemoattractant
- IP-9
- IP9
- MGC102770
- SCYB11
- SCYB9B
- small inducible cytokine B11
- small inducible cytokine subfamily B (Cys-X-Cys), member 11
- small inducible cytokine subfamily B (Cys-X-Cys), member 9B
- small-inducible cytokine B11
- NCBI_Gene: 6373
- UniProtKB: O14625
Human CXCL11 Predicted Functions
Enables CXCR3 chemokine receptor binding activity; chemokine activity; and heparin binding activity. Involved in several processes, including T cell chemotaxis; chemokine-mediated signaling pathway; and positive regulation of release of sequestered calcium ion into cytosol. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of bronchiolitis obliterans; chronic obstructive pulmonary disease; and pulmonary sarcoidosis.
Mouse Cxcl11 Target Information
- Target Symbol: Cxcl11, chemokine (C-X-C motif) ligand 11
- Alias:
- b-R1
- betaR1
- H174
- I-TAC
- IP9
- ITAC
- Scyb11
- SCYB9B
- small inducible cytokine subfamily B (Cys-X-Cys), member 11
- NCBI_Gene: 56066
Mouse Cxcl11 Predicted Functions
Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; chemokine-mediated signaling pathway; and neutrophil chemotaxis. Predicted to be active in extracellular space. Is expressed in head; nasal cavity epithelium; palatal shelf epithelium; palatal shelf mesenchyme; and testis. Orthologous to human CXCL11 (C-X-C motif chemokine ligand 11).
Rat Cxcl11 Target Information
- Target Symbol: Cxcl11, C-X-C motif chemokine ligand 11
- Alias:
- C-X-C motif chemokine 11
- chemokine (C-X-C motif) ligand 11
- SCYB11
- NCBI_Gene: 305236
- UniProtKB: Q7TNL0
Rat Cxcl11 Predicted Functions
Enables chemokine activity. Involved in immune response. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Orthologous to human CXCL11 (C-X-C motif chemokine ligand 11).
