C-X-C motif chemokine 11 (CXCL11), also known as interferon-induced T-cell alpha chemokine (I-TAC), is a small molecule cytokine in the CXC chemokine family. Its gene is located on human chromosome 4, as are many other members of the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas, and liver, moderately expressed in thymus, spleen, and lung, and poorly expressed in small intestine, placenta, and prostate tissues.CXCL11 gene expression is strongly induced by IFN-γ and IFN-β, and weakly by IFN-α. CXCL11 acts on target cells by interacting with CXCR3, a cell surface chemokine receptor. CXCL11 converges activated T cells.CXCL11 has angiogenic inhibitory effects and is involved in allergic contact dermatitis, atherosclerosis, mycosis fungoides (a type of T-cell lymphoma), and immune-mediated disorders of the central nervous system such as multiple sclerosis.CXCL11 has been shown to inhibit the expression of the CXCL11 gene, whereas IFN-α is less inducible.