HGNC ID: 16028
Target Abstract:
Interleukin 33 (IL-33), also known as NF-HEV and DVS27, is a member of the IL-1 family with a molecular weight of 30 kDa, and is secreted by a variety of cell types including fibroblasts, mast cells, dendritic cells, macrophages, osteoblasts, endothelial cells, and epithelial cells.IL-33 induces the secretion of type II cytokines by helper T cells, mast cells, eosinophils, and basophils. Type II cytokines are secreted by granulocytes.IL-33 mediates its biological functions by binding to the receptor ST2 and IL-1 receptor accessory protein (IL1RAP) and activating extracellular molecules in the NF-κB and MAP kinase signaling pathways that can induce the secretion of type II cytokines (e.g., IL-5 and IL-13) from polarized Th2 cells. After injection of IL-33, it induces type II cytokines in vivo, which is thought to induce severe pathological changes in mucosal organs.
IL33 Target Infomation Overview
- Target Symbol: IL33, interleukin 33
- Gene Groups: Interleukins
- Alias: DVS27; DKFZp586H0523; NF-HEV; IL1F11
- Previous Names: C9orf26
- Alias Names: DVS27-related protein; nuclear factor for high endothelial venules; interleukin-1 family, member 11; chromosome 9 open reading frame 26 (NF-HEV)
IL33, interleukin 33 Target Infomation by Species
- Human
- Mouse
- Rat
Human IL33 Target Information
- Target Symbol: IL33, interleukin 33
- Alias:
- C9orf26
- DKFZp586H0523
- DVS27
- DVS27-related protein
- IL-1F11
- IL-33
- IL1F11
- interleukin-1 family member 11
- interleukin-33
- NF-HEV
- NFEHEV
- nuclear factor for high endothelial venules
- nuclear factor from high endothelial venules
- RP11-575C20.2
- NCBI_Gene: 90865
- UniProtKB: O95760
Human IL33 Predicted Functions
Enables cytokine activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of chemokine production; and positive regulation of macrophage activation. Located in nucleoplasm. Part of cytoplasm and nucleus. Implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Biomarker of several diseases, including colitis (multiple); common cold; gout; liver disease (multiple); and tuberculosis (multiple).
Mouse Il33 Target Information
- Target Symbol: Il33, interleukin 33
- Alias:
- 9230117N10Rik
- Il-33
- Il1f11
- NF-HEV
- RIKEN cDNA 9230117N10 gene
- NCBI_Gene: 77125
Mouse Il33 Predicted Functions
Enables cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including interleukin-33-mediated signaling pathway; microglial cell activation involved in immune response; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of macrophage proliferation; positive regulation of cellular defense response; and positive regulation of macromolecule metabolic process. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Used to study Alzheimer’s disease. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33).
Rat Il33 Target Information
- Target Symbol: Il33, interleukin 33
- Alias:
- IL-33
- interleukin-33
- LOC361749
- RGD1311155
- similar to RIKEN cDNA 9230117N10
- NCBI_Gene: 361749
Rat Il33 Predicted Functions
Predicted to enable cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of oligodendrocyte differentiation; and regulation of sensory perception of pain. Located in nucleus. Biomarker of acute myocardial infarction; colon cancer; and diabetes mellitus. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33).
