HGNC ID: 11916
Target Abstract:
Tumor necrosis factor Receptor 1(TNFRI), also known as tumor necrosis factor receptor Superfamily member 1A(TNFRSF1A) and CD120a, is a member of the tumor necrosis factor receptor superfamily. It activates the transcription factor NF-κB, mediates apoptosis and regulates inflammation. Mutations in the TNFRI gene have been linked to an increased risk of multiple sclerosis. Serum levels of TNFRI are elevated in patients with schizophrenia and bipolar disorder, and high levels of TNFRI are associated with more severe psychotic symptoms.
TNFRSF1A Target Infomation Overview
- Target Symbol: TNFRSF1A, TNF receptor superfamily member 1A
- Gene Groups: CD molecules; Tumor necrosis factor receptor superfamily
- Alias: TNF-R; TNFAR; TNFR60; TNF-R-I; CD120a; TNF-R55
- Previous Names: TNFR1
- Alias Names: tumor necrosis factor receptor superfamily, member 1A
TNFRSF1A, TNF receptor superfamily member 1A Target Infomation by Species
- Human
- Mouse
- Rat
Human TNFRSF1A Target Information
- Target Symbol: TNFRSF1A, TNF receptor superfamily member 1A
- Alias:
- CD120a
- FPF
- MGC19588
- MS5
- p55
- p55-R
- p60
- TBP1
- TNF-R
- TNF-R-I
- TNF-R1
- TNF-R55
- TNF-RI
- TNFAR
- TNFR-I
- TNFR1
- TNFR1-d2
- TNFR55
- TNFR60
- tumor necrosis factor binding protein 1
- tumor necrosis factor receptor 1
- tumor necrosis factor receptor 1A isoform beta
- tumor necrosis factor receptor superfamily member 1A
- tumor necrosis factor receptor superfamily, member 1A
- tumor necrosis factor receptor type 1
- tumor necrosis factor receptor type I
- tumor necrosis factor-alpha receptor
- NCBI_Gene: 7132
- UniProtKB: P19438
Human TNFRSF1A Predicted Functions
Enables tumor necrosis factor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of nitrogen compound metabolic process; and tumor necrosis factor-mediated signaling pathway. Located in Golgi membrane; extracellular space; and membrane raft. Part of receptor complex. Implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Biomarker of several diseases, including acquired immunodeficiency syndrome; autoimmune disease (multiple); female reproductive organ cancer (multiple); kidney disease (multiple); and lung disease (multiple).
Mouse Tnfrsf1a Target Information
- Target Symbol: Tnfrsf1a, tumor necrosis factor receptor superfamily, member 1a
- Alias:
- CD120a
- p55
- p55-R
- TNF receptor alpha chain
- TNF-alpha-R1
- TNF-alphaR1
- TNF-R-I
- TNF-R1
- TNF-R55
- TNFalpha-R1
- TNFAR
- Tnfr-2
- Tnfr1
- TNFR60
- TNFRI
- TNFRp55
- tumor necrosis factor receptor 1
- tumor necrosis factor receptor 2
- NCBI_Gene: 21937
Mouse Tnfrsf1a Predicted Functions
Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including negative regulation of cardiac muscle hypertrophy; negative regulation of extracellular matrix constituent secretion; and semi-lunar valve development. Acts upstream of or within several processes, including defense response to bacterium; intrinsic apoptotic signaling pathway in response to DNA damage; and regulation of tumor necrosis factor-mediated signaling pathway. Located in cell surface and membrane raft. Is expressed in several structures, including alimentary system; extraembryonic component; hemolymphoid system; reproductive system; and respiratory system. Used to study autosomal dominant familial periodic fever. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).
Rat Tnfrsf1a Target Information
- Target Symbol: Tnfrsf1a, TNF receptor superfamily member 1A
- Alias:
- MGC105478
- p55
- p60
- TNF-R1
- TNF-RI
- TNFR-1
- TNFR-I
- Tnfr1
- Tumor necrosis factor receptor
- tumor necrosis factor receptor 1
- tumor necrosis factor receptor superfamily member 1A
- tumor necrosis factor receptor superfamily, member 1a
- tumor necrosis factor receptor type I
- NCBI_Gene: 25625
Rat Tnfrsf1a Predicted Functions
Enables protease binding activity; tumor necrosis factor binding activity; and tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to estradiol stimulus; regulation of apoptotic process; and regulation of cytokine production. Located in several cellular components, including cell surface; membrane raft; and mitochondrion. Part of protein-containing complex. Used to study ischemia (multiple); middle cerebral artery infarction; myocardial infarction; uveitis; and visual epilepsy. Biomarker of several diseases, including root resorption; sciatic neuropathy; transient cerebral ischemia; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).
