HGNC ID: 13557
Target Abstract:
Angiotensin-converting enzyme 2 (ACE-2), also known as ACEH (ACE homolog), is an integral membrane protein and zinc metalloproteinase of the ACE family.ACE2 is a key enzyme in the renin-angiotensin system for the regulation of blood pressure.ACE-2 cleaves angiotensin I and II as carboxypeptidases. Specifically, ACE2 cleaves the terminal natriuretic peptide from angiotensin I or the terminal heptapeptide from angiotensin II to produce angiotensin, respectively. The resulting peptides resist the action of angiotensin II and act as vasodilators.ACE-2 has been shown to be a functional receptor for the human coronaviruses SARS-CoV and SARS-CoV-2.
ACE2 Target Infomation Overview
- Target Symbol: ACE2, angiotensin converting enzyme 2
- Alias: ACEH
- Alias Names: peptidyl-dipeptidase A; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2
ACE2, angiotensin converting enzyme 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human ACE2 Target Information
- Target Symbol: ACE2, angiotensin converting enzyme 2
- Alias:
- ACE-related carboxypeptidase
- ACEH
- angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
- angiotensin I converting enzyme 2
- angiotensin-converting enzyme 2
- angiotensin-converting enzyme homolog
- angiotensin-converting enzyme-related carboxypeptidase
- DKFZp434A014
- metalloprotease MPROT15
- peptidyl-dipeptidase A
- truncated angiotensin converting enzyme 2
- NCBI_Gene: 59272
- UniProtKB: Q9BYF1
Human ACE2 Predicted Functions
Enables identical protein binding activity; peptidase activity; and virus receptor activity. Involved in several processes, including angiotensin-mediated drinking behavior; positive regulation of gap junction assembly; and regulation of transmembrane transport. Located in cell surface; extracellular space; and plasma membrane. Part of apical plasma membrane and brush border membrane. Implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Biomarker of congestive heart failure; hypertrophic cardiomyopathy; and pancreatic ductal carcinoma.
Mouse Ace2 Target Information
- Target Symbol: Ace2, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
- Alias:
- 2010305L05Rik
- RIKEN cDNA 2010305L05 gene
- NCBI_Gene: 70008
Mouse Ace2 Predicted Functions
Predicted to enable identical protein binding activity; peptidase activity; and virus receptor activity. Involved in positive regulation of cardiac muscle contraction and tryptophan transport. Located in brush border membrane and cytoplasm. Is expressed in several structures, including brain; cardiovascular system; extraembryonic component; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2).
Rat Ace2 Target Information
- Target Symbol: Ace2, angiotensin I converting enzyme 2
- Alias:
- ACE-related carboxypeptidase
- angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
- angiotensin-converting enzyme 2
- anigotensin-converting enzyme-related carboxypeptidase
- renal angiotensin-converting enzyme 2
- NCBI_Gene: 302668
Rat Ace2 Predicted Functions
Enables carboxypeptidase activity. Involved in maternal process involved in female pregnancy; negative regulation of ERK1 and ERK2 cascade; and negative regulation of smooth muscle cell proliferation. Located in extracellular space and membrane. Used to study glaucoma; myocardial infarction; and thrombosis. Biomarker of hypertension; lung disease; middle cerebral artery infarction; myocardial infarction; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2).
