HGNC ID: 12724
Target Abstract:
Vitonin (VTN), a member of the aggrecan family, is abundantly present in serum, extracellular matrix, and bone. It is a secreted protein that exists as a single chain or in a clamped, double-chained form formed by disulfide bonds.VTN contains three structural domains: an N-terminal growth regulator B structural domain, a central structural domain with homology to heme, and a C-terminal structural domain.VTN promotes cell adhesion and spreading, inhibits membrane disruption of the complement pathway in terminal cells, and binds to a variety of serine protease inhibitors. It is hypothesized to be associated with hemostasis, cell migration, and malignancy.
VTN Target Infomation Overview
- Target Symbol: VTN, vitronectin
- Gene Groups: Receptor ligands; Complement system regulators and receptors
- Alias: VN
- Alias Names: serum spreading factor; somatomedin B; complement S-protein; vitronectin (serum spreading factor, somatomedin B, complement S-protein)
VTN, vitronectin Target Infomation by Species
- Human
- Mouse
- Rat
Human VTN Target Information
- Target Symbol: VTN, vitronectin
- Alias:
- complement S-protein
- epibolin
- S-protein
- serum spreading factor
- serum-spreading factor
- somatomedin B
- V75
- vitronectin (serum spreading factor, somatomedin B, complement S-protein)
- VN
- VNT
- NCBI_Gene: 7448
- UniProtKB: P04004
Human VTN Predicted Functions
Enables integrin binding activity. Involved in several processes, including endodermal cell differentiation; regulation of cellular protein metabolic process; and smooth muscle cell-matrix adhesion. Located in collagen-containing extracellular matrix; endoplasmic reticulum; and extracellular space. Implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Biomarker of coronary artery disease and diabetic retinopathy.
Mouse Vtn Target Information
- Target Symbol: Vtn, vitronectin
- Alias:
- AI256434
- expressed sequence AI256434
- Vn
- NCBI_Gene: 22370
Mouse Vtn Predicted Functions
Enables extracellular matrix binding activity. Involved in oligodendrocyte differentiation. Acts upstream of or within cell-matrix adhesion; extracellular matrix organization; and positive regulation of cell-substrate adhesion. Located in extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; metanephros; and retina. Human ortholog(s) of this gene implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Orthologous to human VTN (vitronectin).
Rat Vtn Target Information
- Target Symbol: Vtn, vitronectin
- Alias:
- Aa1018
- MGC124961
- Vn
- NCBI_Gene: 29169
Rat Vtn Predicted Functions
Enables collagen binding activity; heparin binding activity; and identical protein binding activity. Involved in liver regeneration and protein polymerization. Located in several cellular components, including Golgi lumen; basement membrane; and rough endoplasmic reticulum lumen. Used to study proteinuria. Biomarker of diabetic retinopathy and visual epilepsy. Human ortholog(s) of this gene implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Orthologous to human VTN (vitronectin).
