HGNC ID: 6526
Target Abstract:
Lipocalin-2, also known as neutrophil gelatinase-associated lipid transport protein (NGAL) or oncogene 24p3, is expressed in neutrophils and is low-expressed in epithelial cells of the kidney, prostate, respiratory and digestive tracts.Lipocalin-2 participates in innate immunity by chelating iron, which in turn may limit bacterial growth.Lipocalin-2 is a kidney injury biomarker and also serves as an early diagnostic for chronic kidney disease, contrast nephropathy and kidney transplantation. Within 2 hours of acute kidney injury (AKI), high levels of Lipocalin-2 are secreted into the blood and urine. The body’s level of Lipocalin-2 is proportional to the severity of AKI.
LCN2 Target Infomation Overview
- Target Symbol: LCN2, lipocalin 2
- Gene Groups: Lipocalins
- Alias: NGAL; 24p3
- Alias Names: oncogene 24p3; neutrophil gelatinase-associated lipocalin; siderocalin; lipocalin 2 (oncogene 24p3)
LCN2, lipocalin 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human LCN2 Target Information
- Target Symbol: LCN2, lipocalin 2
- Alias:
- 24p3
- 25 kDa alpha-2-microglobulin-related subunit of MMP-9
- lipocalin-2
- migration-stimulating factor inhibitor
- MSFI
- neutrophil gelatinase-associated lipocalin
- NGAL
- oncogene 24p3
- p25
- siderocalin
- siderocalin LCN2
- NCBI_Gene: 3934
- UniProtKB: P80188
Human LCN2 Predicted Functions
Enables enterobactin binding activity; identical protein binding activity; and iron ion binding activity. Involved in defense response to bacterium and sequestering of iron ion. Located in extracellular space. Implicated in urinary tract infection. Biomarker of several diseases, including congenital diaphragmatic hernia; hidradenitis suppurativa; hydronephrosis; hypertension (multiple); and kidney disease (multiple).
Mouse Lcn2 Target Information
- Target Symbol: Lcn2, lipocalin 2
- Alias:
- 24p3
- AW212229
- expressed sequence AW212229
- neu-related lipocalin
- NGAL
- NRL
- NCBI_Gene: 16819
Mouse Lcn2 Predicted Functions
Enables iron ion binding activity. Involved in innate immune response; positive regulation of cold-induced thermogenesis; and siderophore transport. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; response to bacterium; and response to virus. Located in extracellular space. Is expressed in several structures, including genitourinary system; gut; liver; lung; and spleen. Human ortholog(s) of this gene implicated in intrahepatic cholangiocarcinoma and urinary tract infection. Orthologous to human LCN2 (lipocalin 2).
Rat Lcn2 Target Information
- Target Symbol: Lcn2, lipocalin 2
- Alias:
- alpha-2-microglobulin-related protein
- alpha-2U globulin-related protein
- lipocalin 2 (oncogene 24p3)
- lipocalin 24p3
- lipocalin-2
- neutrophil gelatinase-associated lipocalin
- NGAL
- p25
- siderocalin LCN2
- Sip24
- NCBI_Gene: 170496
- UniProtKB: P30152
Rat Lcn2 Predicted Functions
Enables enterobactin binding activity; identical protein binding activity; and protease binding activity. Involved in several processes, including cellular response to cytokine stimulus; memory; and regulation of neuron apoptotic process. Located in cytosol and extracellular space. Used to study intrahepatic cholangiocarcinoma and retinal degeneration. Biomarker of several diseases, including acute kidney failure; congenital diaphragmatic hernia; obesity; pulmonary hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in urinary tract infection. Orthologous to human LCN2 (lipocalin 2).
