HGNC ID: 10630
Target Abstract:
Chemokine ligand 4 (CCL4), also known as macrophage inflammatory protein 1β (MIP-1β), is a CC chemokine with specificity for the CCR5 receptor. It chemotaxis natural killer cells, monocytes, and a variety of other immune cells and can be induced to be expressed by many cell types in mice, including mast cells, endothelial cells, macrophages, and CD8+ T cells. The mouse CCL4 cDNAs encode a 92 amino acid residue precursor protein containing a 23 amino acid residue signal peptide, and cleavage of this precursor protein produces a 69 amino acid residue secreted mature protein.CCL4 is an important HIV suppressor produced by CD8+ T cells. Chemokine activity is regulated by G-protein-coupled seven times transmembrane structural domain receptors, CCR1, 5, and 8 These receptors regulate the biological activity of CCL4. In the same cell population, CCL4 is 20-fold weaker in activity than CCL3.
CCL4 Target Infomation Overview
- Target Symbol: CCL4, C-C motif chemokine ligand 4
- Gene Groups: Chemokine ligands
- Alias: MIP-1-beta; Act-2; AT744.1
- Previous Names: LAG1; SCYA4
- Alias Names: small inducible cytokine A4 (homologous to mouse Mip-1b); chemokine (C-C motif) ligand 4
CCL4, C-C motif chemokine ligand 4 Target Infomation by Species
- Human
- Mouse
- Rat
Human CCL4 Target Information
- Target Symbol: CCL4, C-C motif chemokine ligand 4
- Alias:
- ACT2
- AT744.1
- C-C motif chemokine 4
- CC chemokine ligand 4
- chemokine (C-C motif) ligand 4
- G-26
- G-26 T-lymphocyte-secreted protein
- HC21
- LAG-1
- LAG1
- lymphocyte activation gene 1 protein
- lymphocyte-activation gene 1
- macrophage inflammatory protein 1-beta
- MGC104418
- MGC126025
- MGC126026
- MIP-1-beta
- MIP-1-beta(1-69)
- MIP1B
- MIP1B1
- PAT 744
- SCYA2
- SCYA4
- secreted protein G-26
- SIS-gamma
- small inducible cytokine A4 (homologous to mouse Mip-1b)
- small-inducible cytokine A4
- T-cell activation protein 2
- NCBI_Gene: 6351
- UniProtKB: P13236
Human CCL4 Predicted Functions
Enables CCR1 chemokine receptor binding activity; CCR5 chemokine receptor binding activity; and identical protein binding activity. Involved in several processes, including negative regulation by host of viral transcription; positive regulation of calcium-mediated signaling; and positive regulation of natural killer cell chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in acquired immunodeficiency syndrome. Biomarker of several diseases, including Plasmodium falciparum malaria; autoimmune disease (multiple); cystic fibrosis; lung disease (multiple); and nose disease (multiple).
Mouse Ccl4 Target Information
- Target Symbol: Ccl4, chemokine (C-C motif) ligand 4
- Alias:
- Act-2
- AT744.1
- macrophage inflammatory protein-1 beta
- MIP-1 beta
- MIP-1B
- Mip1b
- Scya4
- small inducible cytokine A4
- NCBI_Gene: 20303
Mouse Ccl4 Predicted Functions
Predicted to enable chemokine receptor binding activity and identical protein binding activity. Acts upstream of or within cellular response to xenobiotic stimulus. Located in extracellular space. Is expressed in central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and human immunodeficiency virus infectious disease. Orthologous to several human genes including CCL4L2 (C-C motif chemokine ligand 4 like 2).
Rat Ccl4 Target Information
- Target Symbol: Ccl4, C-C motif chemokine ligand 4
- Alias:
- C-C motif chemokine 4
- chemokine (C-C motif) ligand 4
- macrophage inflammatory protein 1-beta
- macrophage inflammatory protein-1 beta
- MIP-1-beta
- Mip1-b
- Scya4
- small inducible cytokine A4
- small-inducible cytokine A4
- NCBI_Gene: 116637
Rat Ccl4 Predicted Functions
Enables chemokine activity. Involved in several processes, including leukocyte chemotaxis; positive regulation of tumor necrosis factor production; and positive regulation of vascular permeability. Predicted to be active in extracellular space. Biomarker of anti-basement membrane glomerulonephritis; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and human immunodeficiency virus infectious disease. Orthologous to several human genes including CCL4L2 (C-C motif chemokine ligand 4 like 2).
