HGNC ID: 990
Target Abstract:
B-cell lymphoma 2 (Bcl-2) is a founding member of the Bcl-2 family of regulatory proteins that can modulate cell apoptosis by inducing apoptosis (pro-apoptotic) or inhibiting apoptosis (anti-apoptotic). Bcl-2 is well-established as an important anti-apoptotic protein and is classified as an oncogene. It regulates mitochondrial dynamics and is involved in the regulation of mitochondrial fusion and fission. Additionally, in pancreatic beta cells, Bcl-2 and Bcl-XL are involved in controlling metabolic activity and insulin secretion. Genetic damage to the Bcl-2 gene can lead to various cancers, including melanoma, breast cancer, prostate cancer, chronic lymphocytic leukemia, and lung cancer. It may also be associated with schizophrenia and autoimmune diseases. Bcl-2 is also implicated in resistance to cancer treatment.
BCL2 Target Infomation Overview
- Target Symbol: BCL2, BCL2 apoptosis regulator
- Gene Groups: Protein phosphatase 1 regulatory subunits; BCL2 family
- Alias: Bcl-2; PPP1R50
- Alias Names: protein phosphatase 1, regulatory subunit 50; B-cell CLL/lymphoma 2; BCL2, apoptosis regulator
BCL2, BCL2 apoptosis regulator Target Infomation by Species
- Human
- Mouse
- Rat
Human BCL2 Target Information
- Target Symbol: BCL2, BCL2 apoptosis regulator
- Alias:
- apoptosis regulator Bcl-2
- B-cell CLL/lymphoma 2
- b-cell leukemia/lymphoma 2
- Bcl-2
- Bcl-2a
- Bcl-2ß
- BCL2, apoptosis regulator
- PPP1R50
- protein phosphatase 1, regulatory subunit 50
- NCBI_Gene: 596
- UniProtKB: P10415
Human BCL2 Predicted Functions
Enables several functions, including BH3 domain binding activity; enzyme binding activity; and protein heterodimerization activity. Involved in several processes, including B cell receptor signaling pathway; negative regulation of apoptotic process; and positive regulation of B cell proliferation. Acts upstream of or within several processes, including B cell proliferation; apoptotic signaling pathway; and negative regulation of apoptotic process. Located in endoplasmic reticulum; mitochondrial outer membrane; and nucleus. Part of pore complex. Implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; prostate cancer; and urinary bladder cancer. Biomarker of several diseases, including cervix uteri carcinoma in situ; ductal carcinoma in situ; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and urinary system cancer (multiple).
Mouse Bcl2 Target Information
- Target Symbol: Bcl2, B cell leukemia/lymphoma 2
- Alias:
- AW986256
- Bcl-2
- C430015F12Rik
- D630044D05Rik
- D830018M01Rik
- expressed sequence AW986256
- RIKEN cDNA C430015F12 gene
- RIKEN cDNA D630044D05 gene
- RIKEN cDNA D830018M01 gene
- NCBI_Gene: 12043
Mouse Bcl2 Predicted Functions
Enables protein phosphatase 2A binding activity. Involved in several processes, including hair follicle morphogenesis; mitochondrion organization; and negative regulation of reactive oxygen species metabolic process. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and negative regulation of programmed cell death. Located in several cellular components, including mitochondrial membrane; myelin sheath; and nuclear membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb; and sensory organ. Used to study oligomeganephronia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer’s disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).
Rat Bcl2 Target Information
- Target Symbol: Bcl2, BCL2, apoptosis regulator
- Alias:
- apoptosis regulator Bcl-2
- B cell lymphoma 2 associated oncogene
- B-cell CLL/lymphoma 2
- B-cell leukemia/lymphoma 2
- Bcl-2
- Bcl-2alpha
- Bcl2-like protein
- NCBI_Gene: 24224
Rat Bcl2 Predicted Functions
Enables BH domain binding activity. Involved in several processes, including response to peptide; response to purine-containing compound; and response to vitamin. Located in cytosol; mitochondrial crista; and perinuclear region of cytoplasm. Used to study several diseases, including brain ischemia (multiple); end stage renal disease; gastric ulcer; intestinal disease (multiple); and status epilepticus. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; brain disease (multiple); hypertension (multiple); intrinsic cardiomyopathy (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; prostate cancer; and urinary bladder cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).
