HGNC ID: 5962
Target Abstract:
Interleukin 10 (IL-10) is a homodimer consisting of 2 subunits 178 amino acids long. In humans, it is encoded by the IL-10 gene located on chromosome 1 and consists of 5 exons.IL-10 is secreted mainly by monocytes and to a lesser extent by lymphocytes, type II helper T-cells (Th2), mast cells, CD4+CD25+Foxp3+ regulatory T-cells, and partially activated T-cells and B-cells. It has multiple effects on immune regulation and inflammation. It down-regulates Th1 cytokines, class II MHC antigens and co-stimulatory molecules in macrophages. It also enhances B cell survival, proliferation and antibody secretion.IL-10 blocks NF-κB activity and is involved in the regulation of the JAK-STAT signaling pathway.The immunosuppressive properties of IL-10 suggest a possible clinical application to inhibit rejection after organ transplantation.IL-10 also possesses strong anti-inflammatory properties.
IL10 Target Infomation Overview
- Target Symbol: IL10, interleukin 10
- Gene Groups: Interleukins
- Alias: CSIF; TGIF; IL10A; IL-10
- Alias Names: cytokine synthesis inhibitory factor; T-cell growth inhibitory factor
IL10, interleukin 10 Target Infomation by Species
- Human
- Mouse
- Rat
Human IL10 Target Information
- Target Symbol: IL10, interleukin 10
- Alias:
- CSIF
- cytokine synthesis inhibitory factor
- GVHDS
- IL-10
- IL10A
- interleukin-10
- MGC126450
- MGC126451
- T-cell growth inhibitory factor
- TGIF
- NCBI_Gene: 3586
- UniProtKB: P22301
Human IL10 Predicted Functions
Enables protein dimerization activity. Involved in several processes, including negative regulation of cellular catabolic process; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including negative regulation of B cell proliferation; positive regulation of B cell apoptotic process; and positive regulation of signaling receptor activity. Located in extracellular space. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Biomarker of several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); eye disease (multiple); female reproductive organ cancer (multiple); and hematologic cancer (multiple).
Mouse Il10 Target Information
- Target Symbol: Il10, interleukin 10
- Alias:
- cytokine synthesis inhibitory factor
- IL-10
- Il-10
- NCBI_Gene: 16153
Mouse Il10 Predicted Functions
Enables cytokine activity. Involved in several processes, including negative regulation of cell death; negative regulation of heterotypic cell-cell adhesion; and negative regulation of vascular associated smooth muscle cell proliferation. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; negative regulation of cytokine production; and response to bacterium. Located in extracellular space. Is expressed in colon; liver; thymus; and thymus primordium. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human IL10 (interleukin 10).
Rat Il10 Target Information
- Target Symbol: Il10, interleukin 10
- Alias:
- CSIF
- cytokine synthesis inhibitory factor
- If2a
- IL-10
- IL10X
- interferon 2a
- interleukin-10
- NCBI_Gene: 25325
Rat Il10 Predicted Functions
Enables interleukin-10 receptor binding activity. Involved in several processes, including cellular response to estradiol stimulus; liver regeneration; and negative regulation of nitric oxide biosynthetic process. Located in extracellular space. Used to study several diseases, including lung disease (multiple); perinatal necrotizing enterocolitis; sciatic neuropathy; toxic encephalopathy; and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); decubitus ulcer; lung disease (multiple); obstructive sleep apnea; and postpartum depression. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human IL10 (interleukin 10).
