HGNC ID: 5476
Target Abstract:
The superfamily of insulin-like growth factor (IGF)-binding proteins consists of six high-affinity IGF-binding proteins (IGFBPs) and at least four other low-affinity binding proteins called IGFBP-associated proteins (IGFBP-rPs).IGFBP7, a low-affinity IGF-binding protein, plays an essential role in the regulation of a wide range of cell types, including the stimulation of prostacyclin production and cellular adhesion of insulin-like growth factor (IGF) action . Some IGFBPs may also have intrinsic biological activities that are independent of their ability to bind IGF proteins.IGFBP7 levels have been associated with cancer development. Loss of IGFBP7 expression has been associated with poor survival and tumor chemoresistance in several cancer types. IGFBP7 has also been identified as a cell cycle arrest biomarker for acute kidney injury in humans and as a prognostic indicator for early acute kidney injury development.
IGFBP7 Target Infomation Overview
- Target Symbol: IGFBP7, insulin like growth factor binding protein 7
- Gene Groups: I-set domain containing
- Alias: MAC25; IGFBP-7; PSF; FSTL2
- Alias Names: insulin-like growth factor binding protein 7
IGFBP7, insulin like growth factor binding protein 7 Target Infomation by Species
- Human
- Mouse
- Rat
Human IGFBP7 Target Information
- Target Symbol: IGFBP7, insulin like growth factor binding protein 7
- Alias:
- AGM
- angiomodulin
- FSTL2
- IBP-7
- IGF-binding protein 7
- IGFBP-7
- IGFBP-7v
- IGFBP-rP1
- IGFBPRP1
- insulin-like growth factor binding protein 7
- insulin-like growth factor-binding protein 7
- MAC25
- PGI2-stimulating factor
- prostacyclin-stimulating factor
- PSF
- RAMSVPS
- TAF
- tumor-derived adhesion factor
- NCBI_Gene: 3490
- UniProtKB: Q16270
Human IGFBP7 Predicted Functions
Predicted to enable insulin-like growth factor binding activity. Predicted to be an extracellular matrix structural constituent. Involved in cell adhesion. Located in extracellular exosome. Colocalizes with collagen-containing extracellular matrix.
Mouse Igfbp7 Target Information
- Target Symbol: Igfbp7, insulin-like growth factor binding protein 7
- Alias:
- AGM
- follistatin-like 2
- Fstl2
- mac25
- NCBI_Gene: 29817
Mouse Igfbp7 Predicted Functions
Predicted to enable insulin-like growth factor binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within inner ear development. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7).
Rat Igfbp7 Target Information
- Target Symbol: Igfbp7, insulin-like growth factor binding protein 7
- Alias:
- insulin-like growth factor-binding protein 7
- LOC289560
- NCBI_Gene: 289560
Rat Igfbp7 Predicted Functions
Predicted to enable insulin-like growth factor binding activity. Involved in several processes, including embryo implantation; response to cortisol; and response to retinoic acid. Located in extracellular space. Biomarker of renal cell carcinoma. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7).
