HGNC ID: 6001
Target Abstract:
Interleukin 2 (IL-2) is a 15 kDa glycoprotein that, in humans, is encoded by a single gene located in the q26-28 region of chromosome 4. It is a class of signaling molecules in the immune system that regulates activity against immunocompetent white blood cells (leukocytes, usually lymphocytes).IL-2 is the body’s natural response to microbial infections, distinguishing between foreign and self-antigens.IL-2 functions by interacting with the IL-2 receptor, which consists of three chains, the alpha (CD25), beta (CD122) and gamma chains ( CD132). Monitoring serum levels of IL-2 provides a more detailed perspective on a variety of pathologies, including cancer, infectious diseases, transplant rejection, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, and type I diabetes.
IL2 Target Infomation Overview
- Target Symbol: IL2, interleukin 2
- Gene Groups: Interleukins
- Alias: IL-2; TCGF
- Alias Names: T cell growth factor
IL2, interleukin 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human IL2 Target Information
- Target Symbol: IL2, interleukin 2
- Alias:
- aldesleukin
- IL-2
- interleukin-2
- involved in regulation of T-cell clonal expansion
- lymphokine
- T cell growth factor
- TCGF
- NCBI_Gene: 3558
- UniProtKB: P60568
Human IL2 Predicted Functions
Enables cytokine activity and interleukin-2 receptor binding activity. Involved in leukocyte activation involved in immune response; positive regulation of interleukin-17 production; and positive regulation of tyrosine phosphorylation of STAT protein. Acts upstream of or within negative regulation of B cell apoptotic process; positive regulation of B cell proliferation; and positive regulation of activated T cell proliferation. Predicted to be located in extracellular space. Implicated in several diseases, including Takayasu’s arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including Zellweger syndrome; aggressive periodontitis; anogenital venereal wart; autoimmune disease (multiple); and uveitis (multiple).
Mouse Il2 Target Information
- Target Symbol: Il2, interleukin 2
- Alias:
- IL-2
- Il-2
- NCBI_Gene: 16183
Mouse Il2 Predicted Functions
Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren’s syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu’s arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2).
Rat Il2 Target Information
- Target Symbol: Il2, interleukin 2
- Alias:
- IL-2
- interleukin-2
- T-cell growth factor
- TCGF
- NCBI_Gene: 116562
- UniProtKB: P17108
Rat Il2 Predicted Functions
Enables carbohydrate binding activity; glycosphingolipid binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of T cell activation; protein kinase C-activating G protein-coupled receptor signaling pathway; and regulation of protein phosphorylation. Located in extracellular space. Used to study cystitis. Biomarker of allergic rhinitis; colorectal carcinoma; and tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Takayasu’s arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2).
