HGNC ID: 500
Target Abstract:
CD13, also known as aminopeptidase N, is a member of the metalloproteinase membrane-associated proteins, type II. CD13 serves as a receptor for coronaviruses, which can cause respiratory diseases in humans and several animal species. As a zinc-binding metalloproteinase, CD13 plays a role in antigen expression on the cell surface by trimming N-terminal amino acids of MHC class II-bound peptides. CD13 is expressed in granulocytes, monocytes and their precursor cells, as well as in the majority of acute myeloid leukemias and a small fraction of acute lymphoblastic leukemias. In non-hematopoietic cells, CD13 expression is found in various cell types including epithelial cells, renal proximal tubules, intestinal brush border, endothelial cells, fibroblasts, brain cells, bone marrow, osteoclasts, and biliary epithelial cells.
ANPEP Target Infomation Overview
- Target Symbol: ANPEP, alanyl aminopeptidase, membrane
- Gene Groups: Aminopeptidases; CD molecules; M1 metallopeptidases
- Alias: LAP1; gp150; p150
- Previous Names: CD13; PEPN
- Alias Names: aminopeptidase N; aminopeptidase M; microsomal aminopeptidase; membrane alanyl aminopeptidase; alanyl (membrane) aminopeptidase
ANPEP, alanyl aminopeptidase, membrane Target Infomation by Species
- Human
- Mouse
- Rat
Human ANPEP Target Information
- Target Symbol: ANPEP, alanyl aminopeptidase, membrane
- Alias:
- alanyl (membrane) aminopeptidase
- alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)
- alanyl aminopeptidase
- aminopeptidase M
- aminopeptidase N
- AP-M
- AP-N
- APN
- CD13
- GP150
- hAPN
- LAP1
- membrane alanyl aminopeptidase
- microsomal aminopeptidase
- myeloid plasma membrane glycoprotein CD13
- P150
- PEPN
- NCBI_Gene: 290
- UniProtKB: P15144
Human ANPEP Predicted Functions
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including peptide catabolic process; proteolysis; and regulation of blood pressure. Located in endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; and plasma membrane. Biomarker of severe acute respiratory syndrome.
Mouse Anpep Target Information
- Target Symbol: Anpep, alanyl (membrane) aminopeptidase
- Alias:
- aminopeptidase N
- Apn
- Cd13
- NCBI_Gene: 16790
Mouse Anpep Predicted Functions
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of renal sodium excretion; peptide catabolic process; and proteolysis. Predicted to act upstream of or within angiogenesis and cell differentiation. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; metanephros; reproductive system; and sensory organ. Orthologous to human ANPEP (alanyl aminopeptidase, membrane).
Rat Anpep Target Information
- Target Symbol: Anpep, alanyl aminopeptidase, membrane
- Alias:
- alanyl (membrane) aminopeptidase
- alanyl aminopeptidase
- aminopeptidase M
- aminopeptidase N
- AP-M
- AP-N
- Apm
- APN
- cluster of differentiation antigen 13 (CD13)
- kidney aminopeptidase M
- kidney Zn peptidase
- KZP
- Lap1
- leucine arylaminopeptidase 1
- membrane alanine aminopeptidase
- microsomal aminopeptidase
- rAPN
- NCBI_Gene: 81641
Rat Anpep Predicted Functions
Enables aminopeptidase activity and peptide binding activity. Involved in negative regulation of renal sodium excretion; peptide catabolic process; and proteolysis. Located in brush border membrane. Orthologous to human ANPEP (alanyl aminopeptidase, membrane).