HGNC ID: 7173
Target Abstract:
Matrix metalloproteinase 3(MMP-3), also known as stroma-decomposin-1, is encoded by the MMP3 gene in humans. MMP3 expression is regulated primarily at the transcriptional level, where gene promoters respond to a variety of stimuli, including growth factors, cytokines, cancer promoters, and proto-oncogene products. The MMP-3 enzyme degrades types II, III, IV, IX and X collagen, proteoglycans, fibronectin, laminin and elastin. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7 and MMP-9, so MMP-3 plays a key role in connective tissue remodeling. This enzyme is involved in wound repair, atherosclerosis progression and tumor initiation. MMP-3 wild-type and gene-knockout mouse studies have shown that MMP-3 increases blood-brain barrier permeability after traumatic injury. Nuclear MMP-3 functions as a transcription factor and protease.
MMP3 Target Infomation Overview
- Target Symbol: MMP3, matrix metallopeptidase 3
- Gene Groups: M10 matrix metallopeptidases
- Previous Names: STMY1; STMY
- Alias Names: matrix metalloproteinase 3 (stromelysin 1, progelatinase); stromelysin 1
MMP3, matrix metallopeptidase 3 Target Infomation by Species
- Human
- Mouse
- Rat
Human MMP3 Target Information
- Target Symbol: MMP3, matrix metallopeptidase 3
- Alias:
- CHDS6
- matrix metallopeptidase 3 (stromelysin 1, progelatinase)
- matrix metalloproteinase 3 (stromelysin 1, progelatinase)
- matrix metalloproteinase-3
- MGC126102
- MGC126103
- MGC126104
- MMP-3
- proteoglycanase
- SL-1
- STMY
- STMY1
- STR1
- stromelysin-1
- transin-1
- NCBI_Gene: 4314
- UniProtKB: P08254
Human MMP3 Predicted Functions
Enables endopeptidase activity and metallopeptidase activity. Involved in several processes, including cellular response to UV-A; negative regulation of hydrogen peroxide metabolic process; and positive regulation of protein-containing complex assembly. Predicted to be located in cytosol and mitochondrion. Implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Biomarker of several diseases, including Takayasu’s arteritis; arthritis (multiple); autoimmune disease (multiple); conjunctivochalasis; and lung disease (multiple).
Mouse Mmp3 Target Information
- Target Symbol: Mmp3, matrix metallopeptidase 3
- Alias:
- progelatinase
- SLN-1
- SLN1
- Stmy1
- STR-1
- Str1
- stromelysin 1
- stromelysin-1
- NCBI_Gene: 17392
Mouse Mmp3 Predicted Functions
Predicted to enable metalloendopeptidase activity. Involved in several processes, including negative regulation of protein kinase B signaling; positive regulation of oxidative stress-induced cell death; and protein catabolic process. Acts upstream of or within cellular response to amino acid stimulus and regulation of cell migration. Located in cytosol and mitochondrion. Is expressed in several structures, including axial skeleton thoracic region; genitourinary system; liver; oral region epithelium; and palatal shelf. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Orthologous to human MMP3 (matrix metallopeptidase 3).
Rat Mmp3 Target Information
- Target Symbol: Mmp3, matrix metallopeptidase 3
- Alias:
- matrix metalloproteinase 3
- matrix metalloproteinase-3
- MMP-3
- PTR1 protein
- SL-1
- stromelysin-1
- transin-1
- NCBI_Gene: 171045
Rat Mmp3 Predicted Functions
Predicted to enable metalloendopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to interleukin-1; and response to estradiol. Located in several cellular components, including cell body; dendrite; and extracellular space. Part of protein-containing complex. Biomarker of several diseases, including abdominal aortic aneurysm; degenerative disc disease; gastric ulcer; glomerulonephritis (multiple); and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Orthologous to human MMP3 (matrix metallopeptidase 3).
