HGNC ID: 5973
Target Abstract:
Interleukin 13 (IL-13) is located on chromosome 5q31 and shares 30% homology and a similar structure to IL-4.IL-13 is secreted and produced by many cell types, particularly type 2 helper T cells (Th2). Similar to the closely related IL-4, IL-13 has multiple functions for immune cells. Although IL-13 is primarily associated with the induction of airway disease, it also has anti-inflammatory properties.IL-13 induces changes in hematopoietic cells, but these effects may be less important than those of IL-4.IL-13 specifically induces physiological changes in organs that host infections. It also induces many of the features of allergic lung disease, including airway hyperresponsiveness, cuprocyte proliferation, and mucus hypersecretion, all of which can lead to airway obstruction. In addition, IL-13 inhibits HIV-1 replication in primary culture-derived macrophages and may serve as a candidate cytokine for inhibiting HIV infection in monocytes and macrophages in vivo.
IL13 Target Infomation Overview
- Target Symbol: IL13, interleukin 13
- Gene Groups: Interleukins
- Alias: P600; IL-13; ALRH; BHR1; MGC116786; MGC116788; MGC116789
- Alias Names: allergic rhinitis; Bronchial hyperresponsiveness-1 (bronchial asthma)
IL13, interleukin 13 Target Infomation by Species
- Human
- Mouse
- Rat
Human IL13 Target Information
- Target Symbol: IL13, interleukin 13
- Alias:
- allergic rhinitis
- ALRH
- BHR1
- Bronchial hyperresponsiveness-1 (bronchial asthma)
- IL-13
- interleukin-13
- MGC116786
- MGC116788
- MGC116789
- P600
- NCBI_Gene: 3596
- UniProtKB: P35225
Human IL13 Predicted Functions
Predicted to enable cytokine activity and interleukin-13 receptor binding activity. Involved in several processes, including negative regulation of complement-dependent cytotoxicity; negative regulation of endothelial cell apoptotic process; and positive regulation of interleukin-10 production. Located in extracellular region. Implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Biomarker of several diseases, including Plasmodium falciparum malaria; autoimmune disease (multiple); cystic fibrosis; lung disease (multiple); and scleroderma (multiple).
Mouse Il13 Target Information
- Target Symbol: Il13, interleukin 13
- Alias:
- Il-13
- NCBI_Gene: 16163
Mouse Il13 Predicted Functions
Predicted to enable interleukin-13 receptor binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation. Acts upstream of or within cellular response to cytokine stimulus; inflammatory response; and positive regulation of immune effector process. Located in cytoplasm; external side of plasma membrane; and extracellular space. Is expressed in gut; liver; male reproductive gland or organ; and thymus. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13).
Rat Il13 Target Information
- Target Symbol: Il13, interleukin 13
- Alias:
- IL-13
- interleukin-13
- T-cell activation protein P600
- NCBI_Gene: 116553
- UniProtKB: P42203
Rat Il13 Predicted Functions
Enables interleukin-13 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of macromolecule metabolic process; and regulation of cation transmembrane transport. Located in extracellular space. Used to study asthma; extrinsic allergic alveolitis; and lipoid nephrosis. Biomarker of several diseases, including alcoholic hepatitis; middle cerebral artery infarction; peptic esophagitis; prostatic hypertrophy; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13).
