HGNC ID: 3767
Target Abstract:
Vascular endothelial growth factor receptor 3 (VEGF R3), also known as Flt-4, is a tyrosine kinase receptor for VEGF-C and VEGF-D. This protein is involved in the generation and maintenance of lymphatic vessels in the lymphatic endothelium. High expression of VEGF R3 can be found in lymphatic endothelial cells isolated from cancer tissue of lymphoma patients. Mutations in the VEGF R3 gene lead to IA type hereditary lymphedema. Some studies have shown a positive correlation between the expression of VEGF-C, VEGF-D, and VEGFR3 and the involvement of vascular invasion, lymphatic vessels, and lymph nodes. VEGF-C/VEGF-D/VEGFR3 signaling pathway can provide targets for anti lymphangiogenesis therapy of prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer, etc.
FLT4 Target Infomation Overview
- Target Symbol: FLT4, fms related receptor tyrosine kinase 4
- Gene Groups: Receptor tyrosine kinases; I-set domain containing
- Alias: VEGFR3; PCL; VEGFR-3
- Alias Names: vascular endothelial growth factor receptor 3; VEGF receptor-3; Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4; primary congenital lymphedema; fms-related tyrosine kinase 4; fms related tyrosine kinase 4
FLT4, fms related receptor tyrosine kinase 4 Target Infomation by Species
- Human
- Mouse
- Rat
Human FLT4 Target Information
- Target Symbol: FLT4, fms related receptor tyrosine kinase 4
- Alias:
- CHTD7
- Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4
- FLT-4
- FLT41
- fms related tyrosine kinase 4
- fms-like tyrosine kinase 4
- fms-related tyrosine kinase 4
- LMPH1A
- LMPHM1
- PCL
- primary congenital lymphedema
- soluble VEGFR3 variant 1
- soluble VEGFR3 variant 2
- soluble VEGFR3 variant 3
- tyrosine-protein kinase receptor FLT4
- vascular endothelial growth factor receptor 3
- VEGF receptor-3
- VEGFR-3
- VEGFR3
- NCBI_Gene: 2324
- UniProtKB: P35916
Human FLT4 Predicted Functions
Enables several functions, including protein homodimerization activity; protein phosphatase binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of macromolecule metabolic process; and protein phosphorylation. Acts upstream of or within vascular endothelial growth factor receptor signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Part of receptor complex. Implicated in hereditary lymphedema IA. Biomarker of lymphangioma and systemic scleroderma.
Mouse Flt4 Target Information
- Target Symbol: Flt4, FMS-like tyrosine kinase 4
- Alias:
- AI323512
- Chy
- chylous ascites
- expressed sequence AI323512
- Flt-4
- VEGFR-3
- VEGFR3
- NCBI_Gene: 14257
Mouse Flt4 Predicted Functions
Enables vascular endothelial growth factor-activated receptor activity. Involved in lymphangiogenesis; regulation of blood vessel remodeling; and sprouting angiogenesis. Acts upstream of or within lung alveolus development; positive regulation of cell population proliferation; and respiratory system process. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and extraembryonic component. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4).
Rat Flt4 Target Information
- Target Symbol: Flt4, Fms related receptor tyrosine kinase 4
- Alias:
- FLT-4
- FMS-like tyrosine kinase 4
- fms-related tyrosine kinase 4
- LOC360235
- tyrosine-protein kinase receptor FLT4
- vascular endothelial growth factor receptor 3
- VEGFR-3
- Vegfr3
- NCBI_Gene: 114110
Rat Flt4 Predicted Functions
Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in positive regulation of cell growth and vascular endothelial growth factor receptor signaling pathway. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4).
