HGNC ID: 4893
Target Abstract:
Hepatocyte growth factor (HGF) is a paracrine cell growth, motility, and morphogenetic factor that is secreted by mesenchymal stromal cells and serves as a multifunctional cytokine for the majority of cells of epithelial origin.HGF exists in a single-chain form as a 728-amino-acid-residue prepeptide with a 29-amino-acid signaling sequence and a 25-amino-acid precursor sequence.HGF binds the proto-oncogene c-Met receptor then activates a tyrosine kinase signaling cascade, which in turn regulates cell growth, motility and morphogenesis. It plays a central role in angiogenesis, tumorigenesis and tissue regeneration. Human HGF plasmid DNA treatment of cardiomyocytes is currently being tested for potential use as a treatment for coronary artery disease and cardiac injury following myocardial infarction.HGF may also be used as a prognostic indication for chikungunya virus-induced arthralgia. High levels of HGF are associated with with rapid recovery.
HGF Target Infomation Overview
- Target Symbol: HGF, hepatocyte growth factor
- Alias: SF; F-TCF; HGFB; HPTA
- Previous Names: DFNB39
- Alias Names: hepatopoietin A; fibroblast-derived tumor cytotoxic factor; scatter factor; lung fibroblast-derived mitogen; deafness, autosomal recessive 39; hepatocyte growth factor (hepapoietin A; scatter factor)
HGF, hepatocyte growth factor Target Infomation by Species
- Human
- Mouse
- Rat
Human HGF Target Information
- Target Symbol: HGF, hepatocyte growth factor
- Alias:
- deafness, autosomal recessive 39
- DFNB39
- F-TCF
- fibroblast-derived tumor cytotoxic factor
- hepatocyte growth factor (hepapoietin A, scatter factor)
- hepatopoeitin-A
- hepatopoietin-A
- HGFB
- HPTA
- lung fibroblast-derived mitogen
- SF
- NCBI_Gene: 3082
- UniProtKB: P14210
Human HGF Predicted Functions
Enables chemoattractant activity and identical protein binding activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; negative regulation of programmed cell death; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling. Located in membrane. Implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Biomarker of several diseases, including artery disease (multiple); biliary tract disease (multiple); myositis (multiple); retinal disease (multiple); and rheumatoid arthritis (multiple).
Mouse Hgf Target Information
- Target Symbol: Hgf, hepatocyte growth factor
- Alias:
- C230052L06Rik
- HGF/SF
- NK1
- NK2
- RIKEN cDNA C230052L06 gene
- scatter factor
- SF/HGF
- NCBI_Gene: 15234
Mouse Hgf Predicted Functions
Predicted to enable chemoattractant activity; growth factor activity; and identical protein binding activity. Acts upstream of or within several processes, including regulation of MAPK cascade; regulation of cytokine production; and regulation of protein phosphorylation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; embryo mesenchyme; and genitourinary system. Used to study autosomal recessive nonsyndromic deafness 39 and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor).
Rat Hgf Target Information
- Target Symbol: Hgf, hepatocyte growth factor
- Alias:
- hepatocyte growth factor (scatter factor)
- hepatopoeitin-A
- hepatopoietin-A
- HPTA
- scatter factor
- SF
- NCBI_Gene: 24446
- UniProtKB: P17945
Rat Hgf Predicted Functions
Enables growth factor activity. Involved in several processes, including animal organ regeneration; positive regulation of angiogenesis; and positive regulation of myelination. Located in extracellular space. Used to study brain infarction. Biomarker of cholangiocarcinoma. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor).
