HGNC ID: 775
Target Abstract:
Antithrombin-III (AT-III) is a member of the serine protease inhibitor (serpin) superfamily encoded by the SERPINC1 gene. Research has found that AT-III is a biomarker for disseminated intravascular coagulation (DIC). This protein inhibits thrombin and other activated serine proteases in the coagulation system, regulating the cascade of clotting reactions. AT-III is the most important inhibitor of coagulation factors, and even minor changes in AT-III levels can significantly increase the risk of thromboembolism.AT-III can inhibit inflammation through both coagulation-dependent and coagulation-independent mechanisms. In addition to AT-III deficiency, both AT-III and its encoding gene SERPINC1 have been implicated in various diseases such as hypertension and kidney disease.
SERPINC1 Target Infomation Overview
- Target Symbol: SERPINC1, serpin family C member 1
- Gene Groups: Serpin peptidase inhibitors
- Alias: ATIII; MGC22579
- Previous Names: AT3
- Alias Names: antithrombin III; signal peptide antithrombin part 1; coding sequence signal peptide antithrombin part 1; antithrombin (aa 375-432); serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINC1, serpin family C member 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human SERPINC1 Target Information
- Target Symbol: SERPINC1, serpin family C member 1
- Alias:
- antithrombin III
- antithrombin III isoform
- antithrombin-III
- AT3
- AT3D
- ATIII
- ATIII-R2
- ATIII-T1
- ATIII-T2
- MGC22579
- serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
- serine-cysteine proteinase inhibitor clade C member 1
- serpin C1
- serpin peptidase inhibitor clade C member 1
- serpin peptidase inhibitor, clade C (antithrombin), member 1
- THPH7
- NCBI_Gene: 462
- UniProtKB: P01008
Human SERPINC1 Predicted Functions
Enables identical protein binding activity and protease binding activity. Predicted to be involved in negative regulation of endopeptidase activity. Located in extracellular space. Part of collagen-containing extracellular matrix. Implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Biomarker of acute kidney failure; nephrotic syndrome; osteonecrosis; and type 2 diabetes mellitus.
Mouse Serpinc1 Target Information
- Target Symbol: Serpinc1, serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
- Alias:
- AI114908
- anti-thrombin 3
- antithrombin
- At-3
- At3
- ATIII
- expressed sequence AI114908
- NCBI_Gene: 11905
Mouse Serpinc1 Predicted Functions
Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity and response to nutrient. Predicted to act upstream of or within blood coagulation and negative regulation of peptidase activity. Located in collagen-containing extracellular matrix. Is expressed in embryo; liver; neural tube; and notochord. Used to study antithrombin III deficiency. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1).
Rat Serpinc1 Target Information
- Target Symbol: Serpinc1, serpin family C member 1
- Alias:
- antithrombin III
- antithrombin-III
- LOC304917
- serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
- serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
- serpin peptidase inhibitor, clade C (antithrombin), member 1
- NCBI_Gene: 304917
Rat Serpinc1 Predicted Functions
Enables heparin binding activity and serine-type endopeptidase inhibitor activity. Involved in acute inflammatory response to antigenic stimulus; lactation; and response to nutrient. Located in extracellular space. Used to study thrombosis. Biomarker of familial hyperlipidemia; nephrotic syndrome; and ovarian cancer. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1).
