HGNC ID: 1694
Target Abstract:
CD69 is a type II transmembrane glycoprotein that belongs to the C-type lectin receptor family and is also a member of the NK cell signaling gene complex family. It is the earliest surface antigen expressed after T lymphocyte activation. Once expressed, it serves as a co-stimulatory signal to promote further activation and proliferation of T cells. CD69 is also induced on NK cells, B cells, macrophages, neutrophils, and eosinophils. Activated T cells expressing CD69 are mainly CD8+CD45RO+ and are primarily induced by IL-15 and contact with activated endothelium expressing ICAM-1. The expression of CD69 on activated T cells rapidly decreases when the exogenous stimulus disappears. Therefore, the level of CD69 expression on lymphocytes exposed to antigen stimulation can reflect the degree of cellular response to that antigen.
CD69 Target Infomation Overview
- Target Symbol: CD69, CD69 molecule
- Gene Groups: CD molecules; C-type lectin domain containing
- Alias: CLEC2C
- Alias Names: CD69 antigen (p60, early T-cell activation antigen)
CD69, CD69 molecule Target Infomation by Species
- Human
- Mouse
- Rat
Human CD69 Target Information
- Target Symbol: CD69, CD69 molecule
- Alias:
- activation inducer molecule (AIM/CD69)
- AIM
- BL-AC/P26
- C-type lectin domain family 2 member C
- C-type lectin domain family 2, member C
- CD69 antigen (p60, early T-cell activation antigen)
- CLEC2C
- EA1
- early activation antigen CD69
- early lymphocyte activation antigen
- early T-cell activation antigen p60
- GP32/28
- leukocyte surface antigen Leu-23
- MLR-3
- NCBI_Gene: 969
- UniProtKB: Q07108
Human CD69 Predicted Functions
Enables identical protein binding activity. Predicted to act upstream of or within cellular response to xenobiotic stimulus. Part of protein-containing complex.
Mouse Cd69 Target Information
- Target Symbol: Cd69, CD69 antigen
- Alias:
- 5830438K24Rik
- AI452015
- AIM
- EST AI452015
- RIKEN cDNA 5830438K24 gene
- VEA
- NCBI_Gene: 12515
Mouse Cd69 Predicted Functions
Predicted to enable calcium ion binding activity and identical protein binding activity. Located in external side of plasma membrane. Orthologous to human CD69 (CD69 molecule).
Rat Cd69 Target Information
- Target Symbol: Cd69, Cd69 molecule
- Alias:
- C-type lectin domain family 2 member A
- CD69 antigen
- early activation antigen CD69
- NCBI_Gene: 29187
- UniProtKB: Q5M851
Rat Cd69 Predicted Functions
Enables calcium ion binding activity. Predicted to be involved in complement activation, lectin pathway. Predicted to act upstream of or within cellular response to xenobiotic stimulus. Predicted to be located in cell surface. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane. Orthologous to human CD69 (CD69 molecule).