HGNC ID: 2434
Target Abstract:
Granulocyte macrophage colony stimulating factor (GM-CSF) is a cytokine that regulates the growth of white blood cells. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. In addition, it also has activity on hematopoietic and non hematopoietic lineage cells. GM-CSF is used as a drug to stimulate the production of white blood cells and prevent neutropenia caused by chemotherapy. Recently, clinical trials are underway to evaluate the efficacy of GM-CSF as a potential vaccine adjuvant in HIV infected patients. Related studies have reported that some cancer patients (including lung cancer and acute myeloid leukemia) have high levels of GM-CSF in their serum, as well as in peripheral blood and scale extracts from patients with bronchial asthma.
CSF2 Target Infomation Overview
- Target Symbol: CSF2, colony stimulating factor 2
- Alias: GM-CSF; GMCSF
- Alias Names: sargramostim; molgramostim; granulocyte-macrophage colony stimulating factor; colony stimulating factor 2 (granulocyte-macrophage)
CSF2, colony stimulating factor 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human CSF2 Target Information
- Target Symbol: CSF2, colony stimulating factor 2
- Alias:
- colony stimulating factor 2 (granulocyte-macrophage)
- colony-stimulating factor
- CSF
- GMCSF
- granulocyte macrophage-colony stimulating factor
- granulocyte-macrophage colony stimulating factor
- granulocyte-macrophage colony-stimulating factor
- MGC131935
- MGC138897
- molgramostim
- molgramostin
- sargramostim
- NCBI_Gene: 1437
- UniProtKB: P04141
Human CSF2 Predicted Functions
Enables cytokine activity. Involved in several processes, including cellular response to granulocyte macrophage colony-stimulating factor stimulus; myeloid leukocyte differentiation; and positive regulation of macromolecule metabolic process. Located in extracellular space and intracellular membrane-bounded organelle. Implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Biomarker of COVID-19; asthma; chronic obstructive pulmonary disease; and temporal arteritis.
Mouse Csf2 Target Information
- Target Symbol: Csf2, colony stimulating factor 2 (granulocyte-macrophage)
- Alias:
- colony stimulating factor, granulocyte macrophage
- Csfgm
- Gm-CSf
- GMCSF
- MGI-IGM
- NCBI_Gene: 12981
Mouse Csf2 Predicted Functions
Enables cytokine activity. Acts upstream of or within several processes, including embryonic placenta development; myeloid leukocyte differentiation; and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including genitourinary system; hemolymphoid system; labyrinthine zone; liver; and lung. Used to study pulmonary alveolar proteinosis. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Orthologous to human CSF2 (colony stimulating factor 2).
Rat Csf2 Target Information
- Target Symbol: Csf2, colony stimulating factor 2
- Alias:
- colony stimulating factor 2 (granulocyte-macrophage)
- colony-stimulating factor
- CSF
- Gm-csf
- Gmcsf
- granulocyte-macrophage colony-stimulating factor
- NCBI_Gene: 116630
- UniProtKB: P48750
Rat Csf2 Predicted Functions
Enables cytokine activity. Involved in several processes, including cellular response to lipopolysaccharide; macrophage activation; and response to silicon dioxide. Located in extracellular space. Used to study Parkinsonism and myocardial infarction. Biomarker of abdominal aortic aneurysm; interstitial cystitis; and lung disease (multiple). Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Orthologous to human CSF2 (colony stimulating factor 2).
