HGNC ID: 6149
Target Abstract:
CD11b binds noncovalently to CD18 to form αM-β2 integrin (Mac-1), which binds to CD54 (ICAM-1), C3bi, and fibrinogen.Mac-1 is expressed on macrophages, NK cells, granulocytes, microglial cells, activated lymphocytes, and mouse B-1 cells.CD11b binds to its ligand and participates in the interactions of adherent cells. This antibody also cross recognizes human CD11b and detects this antigen on monocytes, granulocytes and a certain group of NK cells in human peripheral blood.
ITGAM Target Infomation Overview
- Target Symbol: ITGAM, integrin subunit alpha M
- Gene Groups: CD molecules; Integrin alpha subunits; Complement system regulators and receptors
- Alias: MAC-1; CD11b
- Previous Names: CR3A; CD11B
- Alias Names: complement component 3 receptor 3 subunit; macrophage-1 antigen alpha subunit; integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide); integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAM, integrin subunit alpha M Target Infomation by Species
- Human
- Mouse
- Rat
Human ITGAM Target Information
- Target Symbol: ITGAM, integrin subunit alpha M
- Alias:
- antigen CD11b (p170)
- CD11 antigen-like family member B
- CD11B
- cell surface glycoprotein MAC-1 subunit alpha
- complement component 3 receptor 3 subunit
- CR-3 alpha chain
- CR3A
- integrin alpha-M
- integrin, alpha M (complement component 3 receptor 3 subunit)
- integrin, alpha M (complement component receptor 3, alpha)
- leukocyte adhesion receptor MO1
- MAC-1
- MAC1A
- macrophage antigen alpha polypeptide
- macrophage-1 antigen alpha subunit
- MGC117044
- MO1A
- neutrophil adherence receptor alpha-M subunit
- SLEB6
- NCBI_Gene: 3684
- UniProtKB: P11215
Human ITGAM Predicted Functions
Enables heat shock protein binding activity. Involved in ectodermal cell differentiation; positive regulation of neutrophil degranulation; and positive regulation of superoxide anion generation. Located in cell surface; extracellular space; and plasma membrane raft. Implicated in lupus nephritis.
Mouse Itgam Target Information
- Target Symbol: Itgam, integrin alpha M
- Alias:
- Cd11b
- CD11B (p170)
- CD11b/CD18
- complement component receptor 3 alpha
- complement receptor type 3
- CR3
- F730045J24Rik
- Ly-40
- lymphocyte antigen 40
- Mac-1
- Mac-1 alpha
- Mac-1a
- macrophage antigen alpha chain (integrin)
- RIKEN cDNA F730045J24 gene
- NCBI_Gene: 16409
Mouse Itgam Predicted Functions
Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; endocytosis; and positive regulation of neuron death. Acts upstream of or within several processes, including activated T cell proliferation; leukocyte migration; and microglia development. Located in external side of plasma membrane and nucleus. Is integral component of membrane. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; lymphatic vessel; thymus; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M).
Rat Itgam Target Information
- Target Symbol: Itgam, integrin subunit alpha M
- Alias:
- Cd11b
- integrin alpha M
- Integrin alpha-M
- integrin, alpha M
- NCBI_Gene: 25021
Rat Itgam Predicted Functions
Predicted to enable several functions, including complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to contribute to cargo receptor activity. Predicted to be involved in several processes, including endocytosis; positive regulation of myeloid leukocyte mediated immunity; and positive regulation of neuron death. Predicted to act upstream of or within several processes, including activated T cell proliferation; leukocyte migration; and microglia development. Predicted to be located in several cellular components, including external side of plasma membrane; extracellular space; and plasma membrane raft. Predicted to be integral component of membrane. Predicted to be part of integrin alphaM-beta2 complex. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M).