HGNC ID: 616
Target Abstract:
Apolipoprotein H (ApoH), also known as β2-glycoprotein I, is a multifunctional lipoprotein encoded by the APOH gene in humans. It is a glycoprotein synthesized by hepatocytes, and one of its functions is lipid binding. ApoH can bind to various negatively charged substances such as heparin, phospholipids, and sulfated polysaccharides. ApoH is involved in the complex process of coagulation and can alter ADP-mediated platelet aggregation. It binds to phospholipids on the surface of damaged cells, thereby inhibiting the activation of the intrinsic coagulation cascade. Typically, ApoH in the serum exhibits anticoagulant activity by inhibiting clotting factors. Its plasma concentration is closely associated with changes in metabolic syndrome and vascular complications in type 2 diabetes, making it a clinical marker for assessing cardiovascular risk.
APOH Target Infomation Overview
- Target Symbol: APOH, apolipoprotein H
- Gene Groups: Apolipoproteins; Sushi domain containing
- Alias: BG
- Previous Names: B2G1
- Alias Names: beta-2-glycoprotein I; apolipoprotein H (beta-2-glycoprotein I)
APOH, apolipoprotein H Target Infomation by Species
- Human
- Mouse
- Rat
Human APOH Target Information
- Target Symbol: APOH, apolipoprotein H
- Alias:
- activated protein C-binding protein
- anticardiolipin cofactor
- APC inhibitor
- apo-H
- apolipoprotein H (beta-2-glycoprotein I)
- B2G1
- B2GP1
- B2GPI
- beta-2-glycoprotein 1
- beta(2)GPI
- BG
- NCBI_Gene: 350
- UniProtKB: P02749
Human APOH Predicted Functions
Enables identical protein binding activity; lipoprotein lipase activator activity; and phospholipid binding activity. Involved in several processes, including blood coagulation, intrinsic pathway; negative regulation of apoptotic process; and regulation of blood coagulation. Located in cell surface and extracellular space. Part of chylomicron; high-density lipoprotein particle; and very-low-density lipoprotein particle. Colocalizes with collagen-containing extracellular matrix. Implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Biomarker of arteriosclerosis; diabetes mellitus; diabetic retinopathy; macular retinal edema; and type 2 diabetes mellitus.
Mouse Apoh Target Information
- Target Symbol: Apoh, apolipoprotein H
- Alias:
- B2GPI
- beta-2-glycoprotein 1
- beta-2-GPI
- NCBI_Gene: 11818
Mouse Apoh Predicted Functions
Predicted to enable identical protein binding activity; lipoprotein lipase activator activity; and phospholipid binding activity. Acts upstream of or within regulation of blood coagulation. Located in extracellular space. Is expressed in liver lobe and lung. Human ortholog(s) of this gene implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Orthologous to human APOH (apolipoprotein H).
Rat Apoh Target Information
- Target Symbol: Apoh, apolipoprotein H
- Alias:
- apo-H
- apolipoprotein H (beta-2-glycoprotein I)
- B2GPI
- beta-2-glycoprotein 1
- beta-2-glycoprotein I
- beta(2)GPI
- LOC287774
- NCBI_Gene: 287774
Rat Apoh Predicted Functions
Enables lipid binding activity. Involved in several processes, including negative regulation of respiratory burst; positive regulation of triglyceride catabolic process; and triglyceride transport. Located in several cellular components, including cell surface; extracellular space; and plasma membrane. Used to study myocardial infarction and thrombosis. Human ortholog(s) of this gene implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Orthologous to human APOH (apolipoprotein H).
