HGNC ID: 6024
Target Abstract:
CD127 is the alpha chain of the interleukin 7 receptor, which together with CD132 (beta chain) forms a high-affinity receptor.CD127 is expressed on most T cells, but can undergo a decrease after T cell activation, and is also expressed on B cell precursors and monocytes.CD127 expression plays an important role in the maturation and maintenance of T lymphocytes and the immune response.
IL7R Target Infomation Overview
- Target Symbol: IL7R, interleukin 7 receptor
- Gene Groups: CD molecules; Fibronectin type III domain containing; Interleukin receptors
- Alias: CD127; IL7RA
IL7R, interleukin 7 receptor Target Infomation by Species
- Human
- Mouse
- Rat
Human IL7R Target Information
- Target Symbol: IL7R, interleukin 7 receptor
- Alias:
- CD127
- CD127 antigen
- CDW127
- IL-7 receptor subunit alpha
- IL-7R subunit alpha
- IL-7R-alpha
- IL-7RA
- IL7RA
- ILRA
- interleukin 7 receptor alpha chain
- interleukin 7 receptor isoform H5-6
- interleukin-7 receptor subunit alpha
- NCBI_Gene: 3575
- UniProtKB: P16871
Human IL7R Predicted Functions
Enables cytokine receptor activity. Involved in positive regulation of cell population proliferation and positive regulation of receptor signaling pathway via STAT. Located in cytosol; nucleoplasm; and plasma membrane. Implicated in severe combined immunodeficiency and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive.
Mouse Il7r Target Information
- Target Symbol: Il7r, interleukin 7 receptor
- Alias:
- CD127
- IL-7 receptor alpha chain
- IL-7Ralpha
- NCBI_Gene: 16197
Mouse Il7r Predicted Functions
Predicted to enable cytokine receptor activity. Involved in defense response to Gram-positive bacterium. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; negative regulation of T cell mediated cytotoxicity; and positive regulation of T cell differentiation in thymus. Located in external side of plasma membrane. Is expressed in adrenal gland; brain; early conceptus; hemolymphoid system; and lymphatic system. Human ortholog(s) of this gene implicated in severe combined immunodeficiency and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human IL7R (interleukin 7 receptor).
Rat Il7r Target Information
- Target Symbol: Il7r, interleukin 7 receptor
- Alias:
- LOC294797
- interleukin-7 receptor subunit alpha
- NCBI_Gene: 294797
- UniProtKB: D4A3X8
Rat Il7r Predicted Functions
ENCODES a protein that exhibits cytokine receptor activity (ortholog); INVOLVED IN B cell proliferation (ortholog); cell morphogenesis (ortholog); defense response to Gram-positive bacterium (ortholog); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; primary immunodeficiency pathway; ASSOCIATED WITH Acute Lymphoblastic Leukemia, with Lymphomatous Features (ortholog); COVID-19 (ortholog); endometriosis (ortholog); FOUND IN cytosol (ortholog); external side of plasma membrane (ortholog); nucleoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate