HGNC ID: 5246
Target Abstract:
Heat shock proteins (HSP) are a group of highly conserved stress proteins that function primarily as molecular chaperones and are involved in a variety of biological processes including heat resistance, inhibition of apoptosis, regulation of cell development and cell differentiation, and signal transduction. HSP27, also known as HSPB1, is a molecular chaperone in the small molecule heat shock proteome. It is present in many cell types, especially all types of myoblasts, and is overexpressed at different stages of cell differentiation and development.HSP27 is involved in apoptotic signaling pathways and inhibits the activation of procaspase-9. In addition, HSP27 protects actin filaments from fragmentation and also activates proteases.HSP27 may be a potential diagnostic marker, and high levels of HSP27 are present in the serum of breast cancer patients. Phosphorylated HSP27 increases human prostate cancer cell infiltration, promotes cell proliferation and inhibits Fas-induced apoptosis.
HSPB1 Target Infomation Overview
- Target Symbol: HSPB1, heat shock protein family B (small) member 1
- Gene Groups: Small heat shock proteins
- Alias: HSP27; HSP28; Hs.76067; Hsp25; CMT2F
- Alias Names: heat shock 27kD protein 1; heat shock 27kDa protein 1
HSPB1, heat shock protein family B (small) member 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human HSPB1 Target Information
- Target Symbol: HSPB1, heat shock protein family B (small) member 1
- Alias:
- 28 kDa heat shock protein
- CMT2F
- DKFZp586P1322
- epididymis secretory protein Li 102
- estrogen-regulated 24 kDa protein
- heat shock 27 kDa protein
- heat shock 27kD protein 1
- heat shock 27kDa protein 1
- heat shock protein beta-1
- HEL-S-102
- HMN2B
- HS.76067
- HSP 27
- Hsp25
- HSP27
- HSP28
- putative heat shock protein family B member 1 isoform
- SRP27
- stress-responsive protein 27
- NCBI_Gene: 3315
- UniProtKB: P04792
Human HSPB1 Predicted Functions
Enables several functions, including protein folding chaperone; protein homodimerization activity; and protein kinase binding activity. Involved in several processes, including anterograde axonal protein transport; positive regulation of angiogenesis; and positive regulation of endothelial cell migration. Located in cytoplasm and nucleus. Implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Biomarker of focal segmental glomerulosclerosis and rheumatoid arthritis.
Mouse Hspb1 Target Information
- Target Symbol: Hspb1, heat shock protein 1
- Alias:
- heat shock protein, 25 kDa
- Hsp25
- NCBI_Gene: 15507
Mouse Hspb1 Predicted Functions
Enables protein kinase C binding activity and protein kinase C inhibitor activity. Involved in negative regulation of protein kinase activity; positive regulation of cytokine production; and regulation of intracellular signal transduction. Acts upstream of or within negative regulation of apoptotic signaling pathway. Located in Z disc; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and heart. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1).
Rat Hspb1 Target Information
- Target Symbol: Hspb1, heat shock protein family B (small) member 1
- Alias:
- heat shock 27 kDa protein
- heat shock 27 kDa protein 1
- heat shock 27kDa protein 1
- heat shock protein 1
- heat shock protein B1
- heat shock protein beta-1
- HSP 27
- Hsp25
- Hsp27
- NCBI_Gene: 24471
Rat Hspb1 Predicted Functions
Enables ubiquitin binding activity. Involved in several processes, including cellular response to butyrate; cellular response to interleukin-11; and response to ischemia. Located in several cellular components, including myofibril; perikaryon; and postsynaptic density membrane. Part of proteasome complex. Biomarker of Alzheimer’s disease and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1).
