HGNC ID: 6137
Target Abstract:
CD49b, also known as integrin α2, is a 150 kD membrane surface glycoprotein.CD49b (integrin α2) binds noncovalently to CD29 (integrin β1) to form a heterodimer, VLA-2, or platelet glycoprotein Ia/IIa (CD49b/CD29), which mediates adhesion between mature megakaryocytes and platelets and collagen.CD49b is expressed in platelets cells, intestinal epithelial cells, NK cells, epithelial cells, and activated T cells, which play an important role in mediating extracellular matrix cell adhesion.
ITGA2 Target Infomation Overview
- Target Symbol: ITGA2, integrin subunit alpha 2
- Gene Groups: CD molecules; Integrin alpha subunits
- Alias: CD49b
- Previous Names: CD49B
- Alias Names: alpha 2 subunit of VLA-2 receptor; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2, integrin subunit alpha 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human ITGA2 Target Information
- Target Symbol: ITGA2, integrin subunit alpha 2
- Alias:
- alpha 2 subunit of VLA-2 receptor
- BDPLT9
- BR
- CD49 antigen-like family member B
- CD49B
- collagen receptor
- GPIa
- HPA-5
- human platelet alloantigen system 5
- integrin alpha 2
- integrin alpha-2
- integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
- platelet antigen Br
- platelet glycoprotein GPIa
- platelet glycoprotein Ia
- platelet membrane glycoprotein Ia
- very late activation protein 2 receptor, alpha-2 subunit
- VLA-2
- VLA-2 subunit alpha
- VLA2 receptor, alpha-2 subunit
- VLAA2
- NCBI_Gene: 3673
- UniProtKB: P17301
Human ITGA2 Predicted Functions
Enables collagen binding activity involved in cell-matrix adhesion and collagen receptor activity. Involved in several processes, including cell adhesion mediated by integrin; cell surface receptor signaling pathway; and mesodermal cell differentiation. Located in cell surface; focal adhesion; and plasma membrane. Part of integrin alpha2-beta1 complex. Implicated in several diseases, including Behcet’s disease; artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); and von Willebrand’s disease (multiple). Biomarker of type 2 diabetes mellitus.
Mouse Itga2 Target Information
- Target Symbol: Itga2, integrin alpha 2
- Alias:
- CD49B
- DX5
- VLA-2 receptor, alpha 2 subunit
- NCBI_Gene: 16398
Mouse Itga2 Predicted Functions
Enables amyloid-beta binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell migration; and positive regulation of cellular component organization. Predicted to act upstream of or within cell adhesion. Located in basal part of cell and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including Behcet’s disease; artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); and von Willebrand’s disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2).
Rat Itga2 Target Information
- Target Symbol: Itga2, integrin subunit alpha 2
- Alias:
- CD49B
- GPIa
- HPA-5
- integrin alpha 2
- integrin alpha-2
- integrin, alpha 2
- platelet glycoprotein Ia
- NCBI_Gene: 170921
- UniProtKB: A0A0G2K470
Rat Itga2 Predicted Functions
Enables collagen binding activity; integrin binding activity; and laminin binding activity. Involved in several processes, including gland development; positive regulation of cell migration; and positive regulation of cellular component organization. Located in several cellular components, including axon terminus; focal adhesion; and perinuclear region of cytoplasm. Biomarker of placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including Behcet’s disease; artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); and von Willebrand’s disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2).