Target Abstract: Polymeric immunoglobulin receptor, also known as PIGR, is a member of the immunoglobulin superfamily and a Fc receptor. The ectodomain of this receptor consists of five units with homology to the variable units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions. PIGR is expressed on several glandular epithelia including those of liver and breast. The deduced amino-acid sequence has a length of 764 residues and shows an overall similarity of 56% and 64% with the rabbit and rat counterpart. PIGR mediates transcellular transport of polymeric immunoglobulin molecules, and thus facilitates the secretion of IgA and IgM. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment of PIGR.
PIGR Target Infomation Overview
- Target Symbol: PIGR, polymeric immunoglobulin receptor
- Gene Groups: V-set domain containing
- Alias: FLJ22667; MGC125361; MGC125362; poly-Ig receptor, ERBB
- Alias Names: hepatocellular carcinoma associated protein TB6; hepatocellular carcinoma-associated protein TB6
PIGR, polymeric immunoglobulin receptor Target Infomation by Species
- Human
- Mouse
- Rat
Human PIGR Target Information
- Target Symbol: PIGR, polymeric immunoglobulin receptor
- Alias:
- FLJ22667
- hepatocellular carcinoma associated protein TB6
- hepatocellular carcinoma-associated protein TB6
- MGC125361
- MGC125362
- poly-Ig receptor
- NCBI_Gene: 5284
- UniProtKB: P01833
Human PIGR Predicted Functions
Enables polymeric immunoglobulin binding activity and polymeric immunoglobulin receptor activity. Involved in several processes, including cell surface receptor signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste; and immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor. Located in extracellular space and plasma membrane. Part of receptor complex and secretory IgA immunoglobulin complex.
Mouse Pigr Target Information
- Target Symbol: Pigr, polymeric immunoglobulin receptor
- Alias:
- pIgA-R
- RNPIGR2
- NCBI_Gene: 18703
Mouse Pigr Predicted Functions
Predicted to enable epidermal growth factor receptor binding activity; polymeric immunoglobulin binding activity; and polymeric immunoglobulin receptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste; and immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor. Predicted to be located in extracellular space and recycling endosome membrane. Predicted to be part of receptor complex and secretory IgA immunoglobulin complex. Predicted to be active in plasma membrane. Is expressed in large intestine and small intestine. Orthologous to human PIGR (polymeric immunoglobulin receptor).
Rat Pigr Target Information
- Target Symbol: Pigr, polymeric immunoglobulin receptor
- Alias:
- pIgA-R
- poly-Ig receptor
- polymeric IgA receptor
- RNPIGR2
- NCBI_Gene: 25046
Rat Pigr Predicted Functions
Enables epidermal growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste; and immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor. Located in recycling endosome membrane. Orthologous to human PIGR (polymeric immunoglobulin receptor).
