HGNC ID: 12726
Target Abstract:
Vascular hemophilic factor (vWF) is a multimeric glycoprotein present in plasma that produces oversized vWF in the endothelium (Weibel-Palade vesicles), megakaryocytes (platelet alpha-granules), and subendothelial connective tissues. vWF multimers have a very high molecular weight (greater than 20,000 kDa) and consist of more than 80 subunits with a molecular weight of 250 kDa. The main function of vWF is to bind other proteins, especially factor VIII, which plays an important role in platelet adhesion to the wound site, and additionally, it plays an important role in the coagulation process. Therefore, vWF deficiency or dysfunction (vascular hemophilia) will result in a tendency to bleed, most notably in tissues with high blood flow in narrow vessels. Monitoring serum levels of vWF may provide more detailed insight into pathologies such as thrombotic thrombocytopenic purpura, Hyde’s syndrome, and possibly hemolytic uremic syndrome.
VWF Target Infomation Overview
- Target Symbol: VWF, von Willebrand factor
- Gene Groups: Receptor ligands
- Previous Names: F8VWF
- Alias Names: Factor VIII related antigen
VWF, von Willebrand factor Target Infomation by Species
- Human
- Mouse
- Rat
Human VWF Target Information
- Target Symbol: VWF, von Willebrand factor
- Alias:
- coagulation factor VIII VWF
- F8VWF
- VWD
- NCBI_Gene: 7450
- UniProtKB: P04275
Human VWF Predicted Functions
Enables several functions, including chaperone binding activity; identical protein binding activity; and integrin binding activity. Involved in cell-substrate adhesion; platelet activation; and positive regulation of intracellular signal transduction. Located in several cellular components, including Weibel-Palade body; collagen-containing extracellular matrix; and endoplasmic reticulum. Implicated in several diseases, including Behcet’s disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand’s disease (multiple). Biomarker of several diseases, including end stage renal disease; familial combined hyperlipidemia; obesity; osteonecrosis; and von Willebrand’s disease (multiple).
Mouse Vwf Target Information
- Target Symbol: Vwf, Von Willebrand factor
- Alias:
- 6820430P06Rik
- AI551257
- B130011O06Rik
- expressed sequence AI551257
- RIKEN cDNA 6820430P06 gene
- RIKEN cDNA B130011O06 gene
- NCBI_Gene: 22371
Mouse Vwf Predicted Functions
Predicted to enable several functions, including chaperone binding activity; identical protein binding activity; and integrin binding activity. Acts upstream of or within several processes, including liver development; placenta development; and platelet activation. Located in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; extraembryonic component; genitourinary system; leptomeninges; and vitelline blood vessel. Used to study von Willebrand’s disease and von Willebrand’s disease 2. Human ortholog(s) of this gene implicated in several diseases, including Behcet’s disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand’s disease (multiple). Orthologous to human VWF (von Willebrand factor).
Rat Vwf Target Information
- Target Symbol: Vwf, von Willebrand factor
- Alias:
- von Willebrand factor homolog
- NCBI_Gene: 116669
Rat Vwf Predicted Functions
Predicted to enable several functions, including chaperone binding activity; identical protein binding activity; and integrin binding activity. Involved in several processes, including liver regeneration; platelet activation; and response to L-ascorbic acid. Located in collagen-containing extracellular matrix; endoplasmic reticulum; and extracellular space. Used to study transient cerebral ischemia. Biomarker of hypertension; mesangial proliferative glomerulonephritis; myocardial infarction; pulmonary fibrosis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Behcet’s disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand’s disease (multiple). Orthologous to human VWF (von Willebrand factor).
