HGNC ID: 4232
Target Abstract:
Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that promotes the survival of different neuronal subpopulations at different stages of both central and peripheral nervous system development. Functional human GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains.GDNF is produced by support cells, type 1 astrocytes, Schwann cells, neurons, pineal cells, and skeletal muscle cells, and is a secreted protein that promotes the survival of motoneurons, midbrain dopaminergic neurons, Purkinje cells, and sympathetic neurons.The effect of GDNF on the survival of spinal motor neurons is 100-fold more efficient than neurotrophic proteins. In a mouse model of Parkinson’s disease, GDNF was found to improve conditions such as bradykinesia, rigidity and postural instability.
GDNF Target Infomation Overview
- Target Symbol: GDNF, glial cell derived neurotrophic factor
- Gene Groups: GDNF family ligands
- Alias: ATF1; ATF2; HFB1-GDNF
- Alias Names: astrocyte-derived trophic factor; glial cell line derived neurotrophic factor; glial derived neurotrophic factor
GDNF, glial cell derived neurotrophic factor Target Infomation by Species
- Human
- Mouse
- Rat
Human GDNF Target Information
- Target Symbol: GDNF, glial cell derived neurotrophic factor
- Alias:
- astrocyte-derived trophic factor
- ATF
- ATF1
- ATF2
- glial cell line derived neurotrophic factor
- glial cell line-derived neurotrophic factor
- HFB1-GDNF
- hGDNF
- HSCR3
- NCBI_Gene: 2668
- UniProtKB: P39905
Human GDNF Predicted Functions
Enables protein homodimerization activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of morphogenesis of an epithelium; and regulation of RNA metabolic process. Acts upstream of or within several processes, including neural crest cell migration; neuron projection development; and positive regulation of cell population proliferation. Located in Golgi apparatus and extracellular region. Implicated in Hirschsprung’s disease; Parkinsonism; and epilepsy. Biomarker of acoustic neuroma; autoimmune disease (multiple); neurodegenerative disease (multiple); pancreatic cancer; and vasculitis (multiple).
Mouse Gdnf Target Information
- Target Symbol: Gdnf, glial cell line derived neurotrophic factor
- Alias:
- AI385739
- expressed sequence AI385739
- glial cell line-derived neurotrophic factor
- NCBI_Gene: 14573
Mouse Gdnf Predicted Functions
Predicted to enable protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including nervous system development; positive regulation of morphogenesis of an epithelium; and ureteric bud formation. Acts upstream of or within several processes, including negative regulation of neuron apoptotic process; nephron epithelium morphogenesis; and organ induction. Predicted to be located in Golgi apparatus and extracellular region. Predicted to be part of receptor complex. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and integumental system. Used to study Hirschsprung’s disease. Human ortholog(s) of this gene implicated in Hirschsprung’s disease; Parkinsonism; and epilepsy. Orthologous to human GDNF (glial cell derived neurotrophic factor).
Rat Gdnf Target Information
- Target Symbol: Gdnf, glial cell derived neurotrophic factor
- Alias:
- astrocyte-derived trophic factor
- ATF
- glial cell line derived neurotrophic factor
- Glial cell line derived neutrophic factor
- glial cell line-derived neurotrophic factor
- GNDF
- NCBI_Gene: 25453
Rat Gdnf Predicted Functions
Enables protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including animal organ development; cellular response to dexamethasone stimulus; and regulation of morphogenesis of an epithelium. Located in extracellular space. Part of receptor complex. Used to study Parkinsonism and middle cerebral artery infarction. Biomarker of Parkinsonism and sciatic neuropathy. Human ortholog(s) of this gene implicated in Hirschsprung’s disease; Parkinsonism; and epilepsy. Orthologous to human GDNF (glial cell derived neurotrophic factor).
