HGNC ID: 11785
Target Abstract:
Thrombs-1 (THBS-1) is a member of the thrombs-retin family that mediates cell-cell and cell-matrix interactions. The protein can bind to fibrinogen, fipronectin, laminin, type V collagen and integrin α-V/β-1. It plays a role in platelet aggregation, angiogenesis and tumorigenesis. In normal tissues, it is a natural inhibitor of new blood vessel formation and tumorigenesis. THBS-1 also positively and negatively regulates endothelial cell adhesion, movement and growth. By blocking the binding of THBS-1 to the cell surface receptor (CD47), normal tissues become almost immune to tumor radiation therapy and contribute to tumor death.
THBS1 Target Infomation Overview
- Target Symbol: THBS1, thrombospondin 1
- Alias: TSP1; THBS; TSP; THBS-1; TSP-1
- Alias Names: thrombospondin-1p180
THBS1, thrombospondin 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human THBS1 Target Information
- Target Symbol: THBS1, thrombospondin 1
- Alias:
- glycoprotein G
- THBS
- THBS-1
- thrombospondin-1
- thrombospondin-1p180
- thrombospondin-p50
- TSP
- TSP-1
- TSP1
- NCBI_Gene: 7057
- UniProtKB: P07996
Human THBS1 Predicted Functions
Enables several functions, including collagen V binding activity; fibrinogen binding activity; and fibroblast growth factor binding activity. Involved in several processes, including regulation of cell migration; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including negative regulation of endothelial cell chemotaxis; negative regulation of endothelial cell proliferation; and negative regulation of nitric oxide mediated signal transduction. Located in several cellular components, including external side of plasma membrane; extracellular space; and platelet alpha granule. Part of fibrinogen complex. Colocalizes with collagen-containing extracellular matrix. Implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Biomarker of COVID-19; cholangiocarcinoma; obesity; pancreatic cancer (multiple); and urinary bladder cancer.
Mouse Thbs1 Target Information
- Target Symbol: Thbs1, thrombospondin 1
- Alias:
- tbsp1
- Thbs-1
- TSP-1
- TSP1
- NCBI_Gene: 21825
Mouse Thbs1 Predicted Functions
Enables extracellular matrix binding activity. Involved in several processes, including behavioral response to pain; positive regulation of macrophage chemotaxis; and positive regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including cellular response to nitric oxide; circulatory system development; and monocyte aggregation. Located in extracellular space and sarcoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study Sjogren’s syndrome. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human THBS1 (thrombospondin 1).
Rat Thbs1 Target Information
- Target Symbol: Thbs1, thrombospondin 1
- Alias:
- thrombospondin-1
- TSP-1
- Tsp1
- NCBI_Gene: 445442
Rat Thbs1 Predicted Functions
Enables transforming growth factor beta binding activity. Involved in several processes, including cellular response to tumor necrosis factor; positive regulation of transforming growth factor beta production; and response to testosterone. Located in cytoplasm and extracellular space. Biomarker of diabetic retinopathy; heart disease; myocardial infarction; and prostate cancer. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human THBS1 (thrombospondin 1).
