HGNC ID: 29471
Target Abstract:
Layilin (LAYN), a transmembrane protein with a molecular weight of 55 kDa that is homologous to C-type lectin, is present in many cell lines and tissue extracts.LAYN binds specifically to hyaluronic acid, but not to other tested mucopolysaccharides, through its extracellular structural domain, an extracellular matrix component ubiquitously present in most animal tissues and body fluids. It is suggested that LAYN may be involved in the modulation of cellular cortical structures by mediating extracellular matrix-to-cytoskeleton signaling through interactions with different intracellular binding elements.LAYN plays a role in many cellular processes, including cell morphology, adhesion, motility, homeostasis, and signal transduction. In addition, LAYN may play an important role in lung cancer invasion and lymphatic metastasis.
LAYN Target Infomation Overview
- Target Symbol: LAYN, layilin
- Gene Groups: C-type lectin domain containing
- Alias: FLJ30977; FLJ31092
LAYN, layilin Target Infomation by Species
Human
Mouse
Rat
Human LAYN Target Information
- Target Symbol: LAYN, layilin
- Alias:
- FLJ30977
- FLJ31092
- NCBI_Gene: 143903
- UniProtKB: Q6UX15
Human LAYN Predicted Functions
Enables hyaluronic acid binding activity. Located in focal adhesion.
Mouse Layn Target Information
- Target Symbol: Layn, layilin
- Alias:
- E030012M19Rik
- gene model 511, (NCBI)
- Gm511
- LOC244864
- RIKEN cDNA E030012M19 gene
- NCBI_Gene: 244864
Mouse Layn Predicted Functions
Predicted to enable hyaluronic acid binding activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in brain and trigeminal ganglion. Orthologous to human LAYN (layilin).
Rat Layn Target Information
- Target Symbol: Layn, layilin
- Alias:
- LOC500996
- RGD1564444
- similar to layilin
- NCBI_Gene: 500996
Rat Layn Predicted Functions
Predicted to enable hyaluronic acid binding activity. Predicted to be integral component of membrane. Orthologous to human LAYN (layilin).
