HGNC ID: 1674
Target Abstract:
CD3, also known as T3, is a member of the immunoglobulin superfamily and plays a crucial role in antigen recognition, signal transduction, and T cell activation. CD3ε, with a molecular weight of 20 kDa, is one subunit of the CD3 complex, which consists of two CD3ε, one CD3γ, one CD3δ, and one CD3ζ (CD247) subunit. The CD3 complex forms a heterodimer with α/β or γ/δ T cell receptors (TCR). CD3 is expressed on all mature T cells, NKT cells, and some thymocytes.
CD3E Target Infomation Overview
- Target Symbol: CD3E, CD3e molecule
- Gene Groups: CD molecules
- Alias Names: CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex)
CD3E, CD3e molecule Target Infomation by Species
- Human
- Mouse
- Rat
Human CD3E Target Information
- Target Symbol: CD3E, CD3e molecule
- Alias:
- CD3-epsilon
- CD3e antigen, epsilon polypeptide (TiT3 complex)
- CD3e molecule, epsilon (CD3-TCR complex)
- FLJ18683
- IMD18
- T-cell antigen receptor complex, epsilon subunit of T3
- T-cell surface antigen T3/Leu-4 epsilon chain
- T-cell surface glycoprotein CD3 epsilon chain
- T3E
- TCRE
- NCBI_Gene: 916
- UniProtKB: P07766
Human CD3E Predicted Functions
Enables SH3 domain binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in negative regulation of gene expression; positive regulation of T cell proliferation; and positive regulation of gene expression. Located in endoplasmic reticulum and external side of plasma membrane. Part of alpha-beta T cell receptor complex. Implicated in immunodeficiency 18. Biomarker of severe acute respiratory syndrome.
Mouse Cd3e Target Information
- Target Symbol: Cd3e, CD3 antigen, epsilon polypeptide
- Alias:
- AI504783
- CD3
- CD3epsilon
- expressed sequence AI504783
- T3-epsilon chain
- T3e
- NCBI_Gene: 12501
Mouse Cd3e Predicted Functions
Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in nervous system development and positive regulation of cell adhesion. Acts upstream of or within several processes, including positive regulation of T cell activation; positive regulation of cytokine production; and regulation of signal transduction. Located in several cellular components, including dendritic spine; external side of plasma membrane; and immunological synapse. Part of alpha-beta T cell receptor complex. Is expressed in colon and hemolymphoid system. Human ortholog(s) of this gene implicated in immunodeficiency 18. Orthologous to human CD3E (CD3e molecule).
Rat Cd3e Target Information
- Target Symbol: Cd3e, CD3e molecule
- Alias:
- CD3 antigen, epsilon polypeptide
- CD3 molecule, epsilon
- CD3 molecule, epsilon polypeptide
- LOC315609
- T-cell surface glycoprotein CD3 epsilon chain
- NCBI_Gene: 315609
Rat Cd3e Predicted Functions
Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in T cell differentiation in thymus; positive regulation of T cell proliferation; and response to nutrient. Predicted to be located in several cellular components, including cell body; dendritic spine; and immunological synapse. Predicted to be part of alpha-beta T cell receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 18. Orthologous to human CD3E (CD3e molecule).