HGNC ID: 5434
Target Abstract:
Interferons (IFNs) are a group of signaling proteins synthesized and released by host cells in response to pathogens, such as viruses, bacteria, parasites, or tumor cells. In general, virus-infected cells release interferons that cause surrounding cells to increase their antiviral defenses. Based on receptor type, human interferons can be classified into 3 major types: type I interferons, which include IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω, type II interferons (known as IFN-γ in humans), and type III interferons.IFN-β up-regulates and down-regulates a variety of genes through the signaling pathways STAT1 and STAT2, most of which are involved in the IFN-β plays an important role in inducing a broad spectrum of nonspecific antiviral infections, and it also influences cell proliferation and modulates the immune response.
IFNB1 Target Infomation Overview
- Target Symbol: IFNB1, interferon beta 1
- Gene Groups: Interferons
- Alias: IFB; IFF
- Previous Names: IFNB
- Alias Names: interferon, beta 1, fibroblast
IFNB1, interferon beta 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human IFNB1 Target Information
- Target Symbol: IFNB1, interferon beta 1
- Alias:
- fibroblast interferon
- IFB
- IFF
- IFN-beta
- IFNB
- interferon beta
- interferon-beta
- interferon, beta 1
- interferon, beta 1, fibroblast
- MGC96956
- NCBI_Gene: 3456
- UniProtKB: P01574
Human IFNB1 Predicted Functions
Enables chloramphenicol O-acetyltransferase activity and cytokine activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of T-helper 2 cell cytokine production; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within response to exogenous dsRNA. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in COVID-19.
Mouse Ifnb1 Target Information
- Target Symbol: Ifnb1, interferon beta 1, fibroblast
- Alias:
- Ifb
- IFN-beta
- IFNB
- NCBI_Gene: 15977
Mouse Ifnb1 Predicted Functions
Enables cytokine activity and type I interferon receptor binding activity. Involved in B cell proliferation; cellular response to virus; and type I interferon signaling pathway. Acts upstream of or within several processes, including cellular response to organic cyclic compound; defense response to other organism; and negative regulation of osteoclast differentiation. Located in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFNB1 (interferon beta 1).
Rat Ifnb1 Target Information
- Target Symbol: Ifnb1, interferon beta 1
- Alias:
- If1da1
- IFN-beta
- Ifnb
- interferon 1da1
- interferon beta
- Interferon beta 1 fibroblast
- interferon beta 1, fibroblast
- interferon, beta 1
- Interferon, beta 1, fibroblast
- NCBI_Gene: 24481
Rat Ifnb1 Predicted Functions
Predicted to enable chloramphenicol O-acetyltransferase activity; cytokine activity; and type I interferon receptor binding activity. Involved in macrophage activation involved in immune response. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFNB1 (interferon beta 1).
