HGNC ID: 1748
Target Abstract:
CDH1, also known as E-cadherin and CD324, is a calcium-dependent cell adhesion molecule. It consists of five extracellular domains with repeated cadherin motifs, a transmembrane domain, and an intracellular domain that can bind to p120-catenin and β-catenin. In adult tissues, CDH1 is expressed in epithelial tissues where it undergoes continuous regeneration, and its half-life on the cell surface is about 5 hours. Dysfunction or loss of CDH1 function and expression is associated with tumor progression and metastasis. Downregulation of CDH1 expression reduces cell adhesion strength within tissues, leading to increased cell motility. Conversely, it allows cancer cells to penetrate the basement membrane and invade surrounding tissues. Pathologists often use CDH1 for diagnosing different types of breast cancer. Immunohistochemical studies have shown significantly reduced or mostly absent expression of CDH1 in invasive lobular carcinoma compared to invasive ductal carcinoma.
CDH1 Target Infomation Overview
- Target Symbol: CDH1, cadherin 1
- Gene Groups: CD molecules; Type I classical cadherins
- Alias: uvomorulin; CD324
- Previous Names: UVO
- Alias Names: E-Cadherin; cadherin 1, type 1, E-cadherin (epithelial)
CDH1, cadherin 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human CDH1 Target Information
- Target Symbol: CDH1, cadherin 1
- Alias:
- Arc-1
- BCDS1
- cadherin 1, E-cadherin (epithelial)
- cadherin 1, type 1
- cadherin 1, type 1, E-cadherin (epithelial)
- cadherin-1
- calcium-dependent adhesion protein, epithelial
- CAM 120/80
- CD324
- CDHE
- cell-CAM 120/80
- E-Cadherin
- E-cadherin 1
- ECAD
- epithelial cadherin
- LCAM
- UVO
- uvomorulin
- NCBI_Gene: 999
- UniProtKB: P12830
Human CDH1 Predicted Functions
Enables several functions, including GTPase activating protein binding activity; ankyrin binding activity; and beta-catenin binding activity. Involved in several processes, including cellular response to indole-3-methanol; cellular response to lithium ion; and positive regulation of protein import into nucleus. Located in several cellular components, including adherens junction; lateral plasma membrane; and trans-Golgi network. Is integral component of membrane. Part of catenin complex and flotillin complex. Colocalizes with cortical actin cytoskeleton. Implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Biomarker of several diseases, including endocrine gland cancer (multiple); invasive lobular carcinoma; oral squamous cell carcinoma; prostate cancer; and pulmonary fibrosis.
Mouse Cdh1 Target Information
- Target Symbol: Cdh1, cadherin 1
- Alias:
- AA960649
- E-cad
- E-cadherin
- Ecad
- expressed sequence AA960649
- L-CAM
- Um
- UM
- uvomorulin
- NCBI_Gene: 12550
Mouse Cdh1 Predicted Functions
Enables several functions, including alpha-catenin binding activity; beta-catenin binding activity; and identical protein binding activity. Involved in several processes, including cochlea development; embryo implantation; and reproductive structure development. Acts upstream of or within several processes, including bicellular tight junction assembly; epithelial cell development; and regulation of proteolysis. Located in several cellular components, including Schmidt-Lanterman incisure; axon; and basolateral plasma membrane. Part of catenin complex and flotillin complex. Is expressed in several structures, including alimentary system; early conceptus; embryo ectoderm; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1).
Rat Cdh1 Target Information
- Target Symbol: Cdh1, cadherin 1
- Alias:
- cadherin-1
- E-cadherin
- epithelial cadherin
- uvomorulin
- NCBI_Gene: 83502
- UniProtKB: Q9R0T4
Rat Cdh1 Predicted Functions
Predicted to enable several functions, including GTPase activating protein binding activity; alpha-catenin binding activity; and ankyrin binding activity. Involved in several processes, including nervous system development; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; and response to toxic substance. Located in cytoplasm and plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of pulmonary fibrosis and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1).
