HGNC ID: 1705
Target Abstract:
CD86, also known as B7.2, is a transmembrane protein with a molecular weight of 80 kDa. It is expressed on dendritic cells, monocytes, memory T lymphocytes, germinal center B lymphocytes, activated B lymphocytes, and activated T lymphocytes. CD86 belongs to the immunoglobulin superfamily, and its ligands are CD28 and CD152 (CTLA4). CD86 interacts with the co-stimulatory receptor CD28 and the inhibitory receptor CTLA4, serving as a major co-stimulatory factor for inducing T lymphocyte proliferation and IL-2 production.
CD86 Target Infomation Overview
- Target Symbol: CD86, CD86 molecule
- Gene Groups: CD molecules; V-set domain containing; B7 family
- Alias: B7.2; B7-2
- Previous Names: CD28LG2
- Alias Names: B-lymphocyte antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
CD86, CD86 molecule Target Infomation by Species
- Human
- Mouse
- Rat
Human CD86 Target Information
- Target Symbol: CD86, CD86 molecule
- Alias:
- activation B7-2 antigen
- B-lymphocyte activation antigen B7-2
- B-lymphocyte antigen B7-2
- B7-2
- B7-2 antigen
- B7.2
- B70
- BU63
- CD28 antigen ligand 2
- CD28LG2
- CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
- CTLA-4 counter-receptor B7.2
- FUN-1
- LAB72
- MGC34413
- T-lymphocyte activation antigen CD86
- NCBI_Gene: 942
- UniProtKB: P42081
Human CD86 Predicted Functions
Predicted to enable signaling receptor activity. Predicted to be involved in several processes, including CD40 signaling pathway; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Predicted to act upstream of or within defense response to virus and toll-like receptor signaling pathway. Located in centriolar satellite; extracellular exosome; and plasma membrane. Implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Biomarker of several diseases, including autoimmune disease (multiple); cryoglobulinemia; hematologic cancer (multiple); lung disease (multiple); and pulmonary hypertension.
Mouse Cd86 Target Information
- Target Symbol: Cd86, CD86 antigen
- Alias:
- B7-2
- B7.2
- B70
- CD28 antigen ligand
- Cd28l2
- Ly-58
- Ly58
- lymphocyte antigen 58
- MB7-2
- NCBI_Gene: 12524
Mouse Cd86 Predicted Functions
Predicted to enable signaling receptor binding activity. Involved in several processes, including CD40 signaling pathway; activation of phospholipase C activity; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; defense response to virus; and positive regulation of T cell proliferation. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Is expressed in central nervous system and retina. Used to study Guillain-Barre syndrome. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule).
Rat Cd86 Target Information
- Target Symbol: Cd86, CD86 molecule
- Alias:
- B7-2
- cd86 antigen
- membrane glycoprotein
- T-lymphocyte activation antigen CD86
- NCBI_Gene: 56822
Rat Cd86 Predicted Functions
Enables signaling receptor binding activity. Involved in several processes, including defense response to other organism; negative regulation of T cell anergy; and positive regulation of activated T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia and bronchiolitis obliterans. Biomarker of asthma; corneal disease; middle cerebral artery infarction; and orchitis. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule).