HGNC ID: 11848
Target Abstract:
Toll-like receptor 2 (TLR2) is a transmembrane receptor that can be expressed in a variety of cell types, including microglia, monocytes, macrophages, and dendritic cells. TLR forms a family of pattern recognition receptors that play an important role in innate immune responses. A large number of pathogens (such as viruses, bacteria, and fungi) compositionally express a set of mutation-resistant molecules called pathogen-associated molecular patterns (PAMP). These microbial molecular markers can consist of proteins, carbohydrates, lipids, nucleic acids, and/or a combination thereof. A single TLR recognizes different pathogen-associated PMPS, initiating a signaling cascade that promotes an immune response.
TLR2 Target Infomation Overview
- Target Symbol: TLR2, toll like receptor 2
- Gene Groups: CD molecules; Toll like receptors
- Alias: TIL4; CD282
- Alias Names: toll-like receptor 2
TLR2, toll like receptor 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human TLR2 Target Information
- Target Symbol: TLR2, toll like receptor 2
- Alias:
- CD282
- TIL4
- toll-like receptor 2
- toll/interleukin 1 receptor-like 4
- toll/interleukin-1 receptor-like protein 4
- NCBI_Gene: 7097
- UniProtKB: O60603
Human TLR2 Predicted Functions
Enables several functions, including lipopolysaccharide binding activity; peptide binding activity; and peptidoglycan binding activity. Involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Acts upstream of or within positive regulation of NF-kappaB transcription factor activity and response to molecule of bacterial origin. Located in several cellular components, including Golgi apparatus; cell surface; and membrane raft. Is intrinsic component of plasma membrane. Part of Toll-like receptor 1-Toll-like receptor 2 protein complex. Is integral component of plasma membrane. Implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Biomarker of several diseases, including autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); middle ear disease (multiple); and nose disease (multiple).
Mouse Tlr2 Target Information
- Target Symbol: Tlr2, toll-like receptor 2
- Alias:
- Ly105
- NCBI_Gene: 24088
Mouse Tlr2 Predicted Functions
Enables lipoteichoic acid binding activity and peptide binding activity. Involved in several processes, including negative regulation of cellular component organization; positive regulation of cytokine production; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including pattern recognition receptor signaling pathway; regulation of cytokine production; and response to bacterium. Located in external side of plasma membrane. Part of Toll-like receptor 2-Toll-like receptor 6 protein complex. Is expressed in several structures, including brain; early embryo; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2).
Rat Tlr2 Target Information
- Target Symbol: Tlr2, toll-like receptor 2
- Alias:
- toll-like receptor 2 variant 1
- toll-like receptor 2 variant 2
- NCBI_Gene: 310553
Rat Tlr2 Predicted Functions
Enables lipopeptide binding activity. Involved in several processes, including neurogenesis; positive regulation of interleukin-10 production; and response to molecule of bacterial origin. Located in cell body; cell projection; and cell surface. Used to study carotid stenosis; ileitis; keratitis; lung disease (multiple); and renal fibrosis. Biomarker of acute necrotizing pancreatitis; kidney failure; lung disease; pancreatitis; and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2).
