HGNC ID: 7107
Target Abstract:
KI-67, also known as Ki-67 or MKI67, is a protein encoded by the MKI67 gene in humans. Ki-67 is a 350-400kDa nuclear protein and a member of mitosis related proteins of chromosomes. In addition, Ki-67 is involved in ribosomal RNA transcription, and its inactivation inhibits ribosomal RNA synthesis. Ki-67 interacts with 160kDa Hklp2, which promotes centrosome separation and spindle bipolarity. It also interacts directly with NIFK and binds to UBF, thus playing a role in the synthesis of ribosomal RNA. Among patients with ER-positive breast cancer, Ki-67 represents a highly proliferative subgroup, allowing them to benefit more from adjuvant chemotherapy.
MKI67 Target Infomation Overview
- Target Symbol: MKI67, marker of proliferation Ki-67
- Gene Groups: Protein phosphatase 1 regulatory subunits
- Alias: MIB-1; PPP1R105; Ki-67
- Alias Names: protein phosphatase 1, regulatory subunit 105; Molecular Immunology Borstel antibody 1; antigen identified by monoclonal antibody Ki-67
MKI67, marker of proliferation Ki-67 Target Infomation by Species
- Human
- Mouse
- Rat
Human MKI67 Target Information
- Target Symbol: MKI67, marker of proliferation Ki-67
- Alias:
- antigen identified by monoclonal antibody Ki-67
- antigen KI-67
- antigen Ki67
- KIA
- MIB-
- MIB-1
- Molecular Immunology Borstel antibody 1
- PPP1R105
- proliferation marker protein Ki-67
- proliferation-related Ki-67 antigen
- NCBI_Gene: 4288
- UniProtKB: P46013
Human MKI67 Predicted Functions
Enables protein C-terminus binding activity. Involved in regulation of chromosome segregation and regulation of mitotic nuclear division. Located in chromosome; nuclear body; and nucleolus. Colocalizes with condensed chromosome. Implicated in Crohn’s disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Biomarker of several diseases, including Barrett’s esophagus; autoimmune disease of musculoskeletal system (multiple); endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and interstitial cystitis.
Mouse Mki67 Target Information
- Target Symbol: Mki67, antigen identified by monoclonal antibody Ki 67
- Alias:
- D630048A14Rik
- Ki-67
- Ki67
- RIKEN cDNA D630048A14 gene
- NCBI_Gene: 17345
Mouse Mki67 Predicted Functions
Predicted to enable protein C-terminus binding activity. Involved in regulation of chromatin organization. Acts upstream of or within cholangiocyte proliferation; hepatocyte proliferation; and meiotic cell cycle. Located in chromosome; cytoplasm; and nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in Crohn’s disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Orthologous to human MKI67 (marker of proliferation Ki-67).
Rat Mki67 Target Information
- Target Symbol: Mki67, marker of proliferation Ki-67
- Alias:
- antigen identified by monoclonal antibody Ki-67
- antigen KI-67
- LOC291234
- proliferation marker protein Ki-67
- NCBI_Gene: 291234
- UniProtKB: D4A0Y6
Rat Mki67 Predicted Functions
Predicted to enable protein C-terminus binding activity. Involved in several processes, including DNA metabolic process; animal organ regeneration; and cellular response to heat. Located in nucleus. Used to study high grade glioma; leiomyoma; and prostate carcinoma. Biomarker of colon cancer; kidney disease; mucositis; type 2 diabetes mellitus; and urinary bladder cancer. Human ortholog(s) of this gene implicated in Crohn’s disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Orthologous to human MKI67 (marker of proliferation Ki-67).
