HGNC ID: 1662
Target Abstract: Cluster of Differentiation 34 (CD34) is a member of a family of single-pass transmembrane sialomucin proteins, and may function as a cell-cell adhesion factor. CD34 protein is selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. It has been widely used as a stem and progenitor cell marker, and clinical CD34+ stem cell transplantation (CD34+SCT) has been performed for tumor purging. CD34 monoclonal antibodies are widely used to identify and isolate hemopoietic progenitors and to classify acute and chronic leukemias.
CD34 Target Infomation Overview
- Target Symbol: CD34, CD34 molecule
- Gene Groups: CD molecules
- Alias: CD34 antigen
- Alias Names: Hematopoietic progenitor cell antigen CD34, CD34 sialomucin
CD34, CD34 molecule Target Infomation by Species
- Human
- 小鼠 Mouse
- Rat
人 Human CD34 Target Information
- Target Symbol: CD34, CD34 molecule
- Alias:
- CD34 antigen
- hematopoietic progenitor cell antigen CD34
- NCBI_Gene: 947
- UniProtKB: P28906
Human CD34 Predicted Functions
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and carbohydrate binding activity. Involved in several processes, including blood vessel development; regulation of cellular response to stress; and regulation of cytokine production. Located in external side of plasma membrane; intercellular bridge; and perinuclear region of cytoplasm. Biomarker of thyroid gland carcinoma.
Mouse Cd34 Target Information
- Target Symbol: Cd34, CD34 antigen
- Alias:
- AU040960
- expressed sequence AU040960
- NCBI_Gene: 12490
Mouse Cd34 Predicted Functions
Enables sulfate binding activity. Acts upstream of or within leukocyte migration. Located in cytoplasm; external side of plasma membrane; and extracellular region. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; genitourinary system; and skin. Orthologous to human CD34 (CD34 molecule).
Rat Cd34 Target Information
- Target Symbol: Cd34, CD34 molecule
- Alias:
- CD34 antigen
- hematopoietic progenitor cell antigen CD34
- LOC305081
- NCBI_Gene: 305081
Rat Cd34 Predicted Functions
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; carbohydrate binding activity; and sulfate binding activity. Involved in glomerular filtration and mesangial cell-matrix adhesion. Located in apical plasma membrane; basal plasma membrane; and lysosome. Part of glomerular endothelium fenestra. Biomarker of diabetic retinopathy. Orthologous to human CD34 (CD34 molecule).
