HGNC ID: 2707
ACE Target Infomation Overview
- Target Symbol: ACE, angiotensin I converting enzyme
- Gene Groups: CD molecules
- Alias: ACE1; CD143
- Previous Names: DCP1
- Alias Names: peptidyl-dipeptidase A; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
ACE, angiotensin I converting enzyme Target Infomation by Species
- Human
- Mouse
- Rat
Human ACE Target Information
- Target Symbol: ACE, angiotensin I converting enzyme
- Alias:
- ACE1
- angiotensin 1 converting enzyme 1
- angiotensin converting enzyme, somatic isoform
- angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
- angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript
- angiotensin-converting enzyme
- carboxycathepsin
- CD143
- CD143 antigen
- DCP
- DCP1
- dipeptidyl carboxypeptidase 1
- dipeptidyl carboxypeptidase I
- ICH
- kininase II
- MGC26566
- MVCD3
- peptidase P
- testicular ECA
- NCBI_Gene: 1636
- UniProtKB: P12821
Human ACE Predicted Functions
Enables several functions, including chloride ion binding activity; peptidase activity; and protein kinase binding activity. Involved in several processes, including arachidonic acid secretion; peptide metabolic process; and regulation of angiotensin metabolic process. Located in several cellular components, including external side of plasma membrane; extracellular exosome; and lysosome. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Biomarker of several diseases, including chronic myeloid leukemia; intermediate coronary syndrome; lung disease (multiple); pancreatic ductal carcinoma; and renal fibrosis.
Mouse Ace Target Information
- Target Symbol: Ace, angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
- Alias:
- AW208573
- CD143
- expressed sequence AW208573
- NCBI_Gene: 11421
Mouse Ace Predicted Functions
Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including cell proliferation in bone marrow; positive regulation of protein modification process; and regulation of gene expression. Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme).
Rat Ace Target Information
- Target Symbol: Ace, angiotensin I converting enzyme
- Alias:
- angiotensin 1 converting enzyme
- angiotensin 1 converting enzyme 1
- angiotensin converting enzyme
- angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
- angiotensin I converting enzyme 1
- angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1)
- angiotensin-converting enzyme
- angiotensin-converting enzyme-like
- CD143
- Dcp1
- Dipeptidyl carboxypeptidase 1
- Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme)
- dipeptidyl carboxypeptidase I
- kininase II
- LOC102556346
- StsRR92
- NCBI_Gene: 24310
Rat Ace Predicted Functions
Enables heterocyclic compound binding activity; metallopeptidase activity; and peptidyl-dipeptidase activity. Involved in several processes, including animal organ development; negative regulation of transport; and response to corticosteroid. Located in several cellular components, including basal plasma membrane; brush border membrane; and sperm midpiece. Used to study several diseases, including artery disease (multiple); glomerulonephritis (multiple); kidney failure (multiple); lung disease (multiple); and proteinuria (multiple). Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; endomyocardial fibrosis; liver cirrhosis (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme).
