HGNC ID: 7176
Target Abstract:
Matrix metalloproteinase 9(MMP-9), also known as 92Kdaiv-type collagenase, 92kDa gelatinase, or gelatinase B, is an enzyme belonging to the zinc-metalloproteinase family. MMP-9 is involved in extracellular matrix degradation in normal physiological processes (such as embryonic development, reproduction, angiogenesis, bone development, wound callus migration, learning and memory) and pathological processes (such as arthritis, cerebral hemorrhage, and tumor metastasis). MMP-9 and elastase appear to be regulators of neutrophil migration through the basement membrane. MMP-9 plays an important role in blood vessel and neovascularization. It is significantly upregulated during epithelial healing of the human respiratory tract and has been found to be associated with many pathological processes, such as cancer, immune and cardiovascular diseases. Elevated levels of MMP-9 were found in cases of rheumatoid arthritis and focal cerebral ischemia. Its level increases with the development of idiopathic AF.
MMP9 Target Infomation Overview
- Target Symbol: MMP9, matrix metallopeptidase 9
- Gene Groups: M10 matrix metallopeptidases
- Previous Names: CLG4B
- Alias Names: matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
MMP9, matrix metallopeptidase 9 Target Infomation by Species
- Human
- Mouse
- Rat
Human MMP9 Target Information
- Target Symbol: MMP9, matrix metallopeptidase 9
- Alias:
- 92 kDa gelatinase
- 92 kDa type IV collagenase
- CLG4B
- GELB
- macrophage gelatinase
- MANDP2
- matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
- matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
- matrix metalloproteinase-9
- MMP-9
- type V collagenase
- NCBI_Gene: 4318
- UniProtKB: P14780
Human MMP9 Predicted Functions
Enables identical protein binding activity; metalloendopeptidase activity; and serine-type endopeptidase activity. Involved in several processes, including cellular response to UV-A; negative regulation of apoptotic signaling pathway; and positive regulation of keratinocyte migration. Located in extracellular space. Implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); brain disease (multiple); carcinoma (multiple); and lung disease (multiple).
Mouse Mmp9 Target Information
- Target Symbol: Mmp9, matrix metallopeptidase 9
- Alias:
- AW743869
- B/MMP9
- Clg4b
- collagenase IVB, basement membrane, 92 kDa
- expressed sequence AW743869
- Gel B
- Gelatinase B
- gelatinase B
- MMP-9
- NCBI_Gene: 17395
Mouse Mmp9 Predicted Functions
Enables metalloendopeptidase activity. Involved in negative regulation of epithelial cell differentiation involved in kidney development and response to amyloid-beta. Acts upstream of or within several processes, including collagen catabolic process; embryo implantation; and extracellular matrix organization. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; limb mesenchyme; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and lung disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9).
Rat Mmp9 Target Information
- Target Symbol: Mmp9, matrix metallopeptidase 9
- Alias:
- 92 kDa gelatinase
- 92 kDa type IV collagenase
- 92-kDa type IV collagenase
- gelatinase B
- GELB
- matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase)
- matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)
- matrix metalloproteinase-9
- MMP-9
- NCBI_Gene: 81687
Rat Mmp9 Predicted Functions
Enables fibronectin binding activity and metallopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to cytokine stimulus; and cellular response to iron(III) ion. Located in extracellular space. Part of protein-containing complex. Used to study artery disease (multiple); brain ischemia (multiple); congestive heart failure; glomerulosclerosis; and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); chronic obstructive pulmonary disease (multiple); glucose metabolism disease (multiple); and kidney disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9).
