HGNC ID: 10626
Target Abstract:
Chemokine ligand 27 (CCL27), also known as cutaneous T-cell captive chemokine (CTACK), is a small molecular weight cytokine in the CC chemokine family, and its gene is located on human chromosome 9.CCL27 is expressed in many tissues including the gonads, thymus, placenta and skin. In vitro studies have shown that IL-1β or TNF-α stimulates CCL27 overexpression, whereas glucagon-cortin inhibits its expression.CCL27 exerts its chemotactic effect by binding to the chemokine receptor CCR10, which is associated with the homing of memory T-lymphocytes into the skin, and plays a role in T-cell mediated inflammation in the skin. In healthy mice, lymphocytes are recruited at the site of CCL27 injection, whereas in a mouse model of contact hypersensitivity, injection of CCL27-neutralizing antibodies disrupts lymphocyte recruitment.
CCL27 Target Infomation Overview
- Target Symbol: CCL27, C-C motif chemokine ligand 27
- Gene Groups: Chemokine ligands
- Alias: ALP; ILC; CTACK; skinkine; ESkine; PESKY; CTAK
- Previous Names: SCYA27
- Alias Names: CC chemokine ILC; IL-11 Ralpha-locus chemokine; cutaneous T-cell attracting chemokine; small inducible cytokine subfamily A (Cys-Cys), member 27; chemokine (C-C motif) ligand 27
CCL27, C-C motif chemokine ligand 27 Target Infomation by Species
- Human
- Mouse
- Rat
Human CCL27 Target Information
- Target Symbol: CCL27, C-C motif chemokine ligand 27
- Alias:
- ALP
- C-C motif chemokine 27
- CC chemokine ILC
- chemokine (C-C motif) ligand 27
- CTACK
- CTAK
- cutaneous T-cell attracting chemokine
- cutaneous T-cell-attracting chemokine
- ESKINE
- IL-11 R-alpha-locus chemokine
- IL-11 Ralpha-locus chemokine
- ILC
- PESKY
- SCYA27
- skinkine
- small inducible cytokine subfamily A (Cys-Cys), member 27
- small-inducible cytokine A27
- NCBI_Gene: 10850
- UniProtKB: Q9Y4X3
Human CCL27 Predicted Functions
Enables CCR3 chemokine receptor binding activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Predicted to be located in nucleus. Predicted to be active in extracellular region. Biomarker of COVID-19; asthma; and atopic dermatitis.
Mouse Ccl27a Target Information
- Target Symbol: Ccl27a, chemokine (C-C motif) ligand 27A
- Alias:
- ALP
- AW558992
- Ccl27
- chemokine (C-C motif) ligand 27
- chemokine (C-C motif) ligand 27a
- CTACK
- CTAK
- ESkine
- expressed sequence AW558992
- ILC
- mILC
- PESKY
- Scya27
- Scya27a
- skinskine
- small inducible cytokine A27
- small inducible cytokine A27a
- NCBI_Gene: 20301
Mouse Ccl27a Predicted Functions
Enables chemokine activity. Involved in cell chemotaxis. Acts upstream of or within positive regulation of T cell chemotaxis and positive regulation of actin cytoskeleton reorganization. Located in extracellular region and nucleus. Is expressed in several structures, including genitourinary system; hip; liver; sensory organ; and skeleton. Orthologous to human CCL27 (C-C motif chemokine ligand 27).
Rat Ccl27 Target Information
- Target Symbol: Ccl27, C-C motif chemokine ligand 27
- Alias:
- C-C motif chemokine 27
- chemokine (C-C motif) ligand 27
- LOC362505
- NCBI_Gene: 362505
- UniProtKB: D4AAL6
Rat Ccl27 Predicted Functions
Predicted to enable CCR3 chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; positive regulation of T cell chemotaxis; and positive regulation of actin cytoskeleton reorganization. Predicted to act upstream of or within positive regulation of mononuclear cell migration. Predicted to be located in nucleus. Predicted to be active in extracellular region. Orthologous to human CCL27 (C-C motif chemokine ligand 27).
