HGNC ID: 19372
Target Abstract:
Interleukin 31 (IL-31) is a short-chain member of the alpha helical cytokine family with a molecular weight of 24 kDa that is primarily associated with activated T-cells and is preferentially expressed by Th2 cells over Th1 cells. The human IL-31 cDNA encodes a 164 amino acid precursor consisting of a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% amino acid sequence homology in the mature region. IL-31 signals through a receptor complex consisting of IL-31 receptor A (IL-31RA) and tumor suppressor M receptor subunits. These receptor subunits are expressed in activated monocytes and unstimulated epithelial cells.IL-31 signaling is involved in the Jak/STAT pathway, the PI3 kinase/AKT signaling cascade, and the MAP kinase pathway. In addition, IL-31 plays a role in skin inflammation.
IL31 Target Infomation Overview
- Target Symbol: IL31, interleukin 31
- Gene Groups: Interleukins
- Alias: IL-31
IL31, interleukin 31 Target Infomation by Species
- Human
- Mouse
- Rat
Human IL31 Target Information
- Target Symbol: IL31, interleukin 31
- Alias:
- IL-31
- interleukin-31
- NCBI_Gene: 386653
- UniProtKB: Q6EBC2
Human IL31 Predicted Functions
Predicted to enable cytokine activity and oncostatin-M receptor binding activity. Predicted to be involved in immune system process and signal transduction. Located in extracellular space.
Mouse Il31 Target Information
- Target Symbol: Il31, interleukin 31
- Alias:
- 1700013B14Rik
- RIKEN cDNA 1700013B14 gene
- NCBI_Gene: 76399
Mouse Il31 Predicted Functions
Enables cytokine activity and oncostatin-M receptor binding activity. Predicted to act upstream of or within immune system process. Located in extracellular space. Orthologous to human IL31 (interleukin 31).
Rat Il31 Target Information
- Target Symbol: Il31, interleukin 31
- Alias:
- hypothetical protein LOC690028
- interleukin-31
- LOC690028
- NCBI_Gene: 690028
- 暂无
Rat Il31 Predicted Functions
Predicted to enable cytokine activity and oncostatin-M receptor binding activity. Predicted to be located in extracellular space. Orthologous to human IL31 (interleukin 31).
