HGNC ID: 2505
Target Abstract:
Cytotoxic T lymphocyte associated protein 4 (CTLA-4), also known as CD152, is a member of the immunoglobulin superfamily and is expressed on the surface of helper T cells. CTLA-4 is similar to the co stimulatory protein CD28 of T cells, both of which bind to CD80 and CD86. CTLA-4 transmits inhibitory signals to T cells, while CD28 transmits stimulating signals. CTLA-4 can function as an immune checkpoint, downregulate the immune system, and act as a “off" switch when binding to CD80 or CD86 on the surface of antigen presenting cells. Intracellular CTLA-4 is also present in regulatory T cells and plays an important role in their function. The mutation of this gene is related to insulin dependent diabetes, hyperthyroidism, Hashimoto’s thyroiditis, celiac disease, systemic lupus erythematosus, thyroid related ophthalmopathy, primary biliary cirrhosis and other autoimmune diseases. The polymorphism of the CTLA-4 gene is associated with autoimmune diseases such as autoimmune thyroid disease and multiple sclerosis, but this association is usually weak. In systemic lupus erythematosus, it has been found that splicing variants of soluble CTLA-4 are abnormally produced and present in the serum of patients with the disease.
CTLA4 Target Infomation Overview
- Target Symbol: CTLA4, cytotoxic T-lymphocyte associated protein 4
- Gene Groups: CD molecules; V-set domain containing
- Alias: CD152; CD; GSE; CTLA-4
- Previous Names: CELIAC3; IDDM12
- Alias Names: celiac disease 3; insulin-dependent diabetes mellitus 12
CTLA4, cytotoxic T-lymphocyte associated protein 4 Target Infomation by Species
- Human
- Mouse
- Rat
Human CTLA4 Target Information
- Target Symbol: CTLA4, cytotoxic T-lymphocyte associated protein 4
- Alias:
- ALPS5
- CD
- CD152
- cd152 antigen
- CD152 isoform
- celiac disease 3
- CELIAC3
- CTLA-4
- cytotoxic T lymphocyte associated antigen 4 short spliced form
- cytotoxic T-lymphocyte antigen 4
- cytotoxic T-lymphocyte protein 4
- cytotoxic T-lymphocyte-associated antigen 4
- cytotoxic T-lymphocyte-associated protein 4
- cytotoxic T-lymphocyte-associated serine esterase-4
- GRD4
- GSE
- ICOS
- IDDM12
- insulin-dependent diabetes mellitus 12
- ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
- NCBI_Gene: 1493
- UniProtKB: P16410
Human CTLA4 Predicted Functions
Involved in several processes, including B cell receptor signaling pathway; negative regulation of lymphocyte activation; and positive regulation of apoptotic process. Located in several cellular components, including clathrin-coated endocytic vesicle; external side of plasma membrane; and perinuclear region of cytoplasm. Is integral component of plasma membrane. Part of protein complex involved in cell adhesion. Implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); hepatitis B; kidney disease (multiple); and primary immunodeficiency disease (multiple). Biomarker of several diseases, including Sjogren’s syndrome; anogenital venereal wart; hepatitis A; lung disease (multiple); and tropical spastic paraparesis.
Mouse Ctla4 Target Information
- Target Symbol: Ctla4, cytotoxic T-lymphocyte-associated protein 4
- Alias:
- Cd152
- CD152 antigen
- Ctla-4
- cytotoxic T lymphocyte-associated protein 4
- Ly-56
- NCBI_Gene: 12477
Mouse Ctla4 Predicted Functions
Predicted to be involved in several processes, including antigen receptor-mediated signaling pathway; negative regulation of lymphocyte activation; and positive regulation of apoptotic process. Predicted to act upstream of or within adaptive immune response. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); hepatitis B; kidney disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human CTLA4 (cytotoxic T-lymphocyte associated protein 4).
Rat Ctla4 Target Information
- Target Symbol: Ctla4, cytotoxic T-lymphocyte-associated protein 4
- Alias:
- Cd152
- CD152 antigen
- CTLA-4
- cytotoxic T-lymphocyte protein 4
- sCTLA4
- soluble form
- transmembrane form
- NCBI_Gene: 63835
Rat Ctla4 Predicted Functions
Predicted to enable signaling receptor activity. Involved in negative regulation of T cell proliferation and negative regulation of immune response. Predicted to be located in Golgi apparatus; clathrin-coated endocytic vesicle; and perinuclear region of cytoplasm. Predicted to be integral component of plasma membrane. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in external side of plasma membrane. Used to study myocarditis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); hepatitis B; kidney disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human CTLA4 (cytotoxic T-lymphocyte associated protein 4).
