HGNC ID: 15488
Target Abstract:
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of the IL-12p40 subunit and the IL-23p19 subunit, where the p40 subunit is shared by IL-23 and IL-12.The functional receptor for IL-23 has been identified and consists of IL-12Rβ1 and IL-23R.IL-23 plays a role in the immune type 1 polarized T cell response. Although IL-12 potently activates naïve T cells, initial reports suggested that IL-23 preferentially acts on memory T cells to promote their secretion of IFN-γ and proliferation, suggesting an important role in the control of bacterial infections.IL-23 was further described as a key cytokine in the control of inflammation in peripheral tissues.Overexpression of p19 has been associated with multiple organ and inflammation in epithelial tissues including the skin.IL-23 is involved in inflammation in the central nervous system and autoimmune diseases.
IL23A Target Infomation Overview
- Target Symbol: IL23A, interleukin 23 subunit alpha
- Gene Groups: Interleukins
- Alias: SGRF; IL23P19; IL-23; IL-23A; P19
- Alias Names: interleukin-six, G-CSF related factor; interleukin 23, alpha subunit p19
IL23A, interleukin 23 subunit alpha Target Infomation by Species
- Human
- Mouse
- Rat
Human IL23A Target Information
- Target Symbol: IL23A, interleukin 23 subunit alpha
- Alias:
- IL-23
- IL-23 subunit alpha
- IL-23-A
- IL-23A
- IL-23p19
- IL23P19
- interleukin 23 p19 subunit
- interleukin 23, alpha subunit p19
- interleukin-23 subunit alpha
- interleukin-23 subunit p19
- interleukin-six, G-CSF related factor
- JKA3 induced upon T-cell activation
- MGC79388
- P19
- SGRF
- NCBI_Gene: 51561
- UniProtKB: Q9NPF7
Human IL23A Predicted Functions
Contributes to interleukin-23 receptor binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of lymphocyte proliferation; and positive regulation of peptidyl-tyrosine phosphorylation. Part of interleukin-23 complex.
Mouse Il23a Target Information
- Target Symbol: Il23a, interleukin 23, alpha subunit p19
- Alias:
- IL-23
- IL-23p19
- p19
- NCBI_Gene: 83430
Mouse Il23a Predicted Functions
Contributes to interleukin-23 receptor binding activity. Involved in positive regulation of defense response to virus by host; positive regulation of immune response; and positive regulation of neutrophil chemotaxis. Acts upstream of or within T cell proliferation and positive regulation of transcription by RNA polymerase II. Located in extracellular space. Part of interleukin-23 complex. Is expressed in decidua; decidua basalis; embryo; and extraembryonic component. Orthologous to human IL23A (interleukin 23 subunit alpha).
Rat Il23a Target Information
- Target Symbol: Il23a, interleukin 23 subunit alpha
- Alias:
- IL-23 subunit alpha
- IL-23-A
- IL-23p19
- Interleukin 23, alpha subunit p19
- interleukin-23 subunit alpha
- interleukin-23 subunit p19
- MGC114275
- NCBI_Gene: 155140
- UniProtKB: Q91Z84
Rat Il23a Predicted Functions
Predicted to enable cytokine activity. Predicted to contribute to interleukin-23 receptor binding activity. Predicted to be involved in several processes, including positive regulation of cytokine production; positive regulation of lymphocyte activation; and positive regulation of peptidyl-tyrosine phosphorylation. Predicted to act upstream of or within T cell proliferation and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space. Predicted to be part of interleukin-23 complex. Orthologous to human IL23A (interleukin 23 subunit alpha).
