Target Abstract: Amphiregulin (AREG) is an epidermal growth factor (EGF) that belongs to the EGF family. This family also includes TGF-α, HB-EGF, β-cellulin (BTC), epiregulin, and neuroregulin. Human Amphiregulin is a transmembrane glycoprotein with a molecular weight of approximately 50 kDa, consisting of 252 amino acids. It contains an N-terminal propeptide of 81 amino acids, a heparin-binding domain, an EGF-like structural domain, a transmembrane domain composed of 23 amino acids, and a cytoplasmic domain made up of 31 amino acids. The expression and release of the AREG gene are induced by various stimuli such as inflammatory lipids, cytokines, hormones, growth factors, and exogenous drugs. Upon binding to EGFR, AREG activates intracellular signaling pathways, regulating the proliferation, apoptosis, and migration of different cell types, including epithelial cells, fibroblasts, and immune cells (dendritic cells, neutrophils, mast cells, and lymphocytes). AREG plays an important role in lung morphogenesis as well as the development and maturation of the mammary gland, bone tissue, and oocytes. Additionally, AREG plays a critical role in the restoration of tissue integrity following infection or injury.

AREG Target Infomation Overview

• Target Symbol: AREG, amphiregulin
• Gene Groups: Receptor ligands
• Alias: SDGF, AREGB, AR, CRDGF
• Alias Names: schwannoma-derived growth factor, amphiregulin B, Colorectum Cell-Derived Growth Factor

AREG, amphiregulin Target Infomation by Species