HGNC ID: 3431
Target Abstract: Receptor tyrosine-protein kinase ErbB3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family. ErbB3, like the other members of the EGFR family, consists of an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain. ErbB3 has been shown to bind the ligands heregulin and NRG-2, but it can’t mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicate in numerous cancers, including prostate, bladder, and breast tumors.
ERBB3 Target Infomation Overview
- Target Symbol: ERBB3, erb-b2 receptor tyrosine kinase 3
- Gene Groups: Erb-b2 receptor tyrosine kinases
- Alias: LCCS2; HER3; HER-3
- Alias Names: lethal congenital contracture syndrome 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; human epidermal growth factor receptor 3
ERBB3, erb-b2 receptor tyrosine kinase 3 Target Infomation by Species
- Human
- Mouse
- Rat
Human ERBB3 Target Information
- Target Symbol: ERBB3, erb-b2 receptor tyrosine kinase 3
- Alias:
- avian erythroblastosis oncogene b 3
- c-erbB-3
- c-erbB3
- ErbB-3
- erbB3-S
- FERLK
- HER3
- human epidermal growth factor receptor 3
- LCCS2
- MDA-BF-1
- MGC88033
- p180-ErbB3
- p45-sErbB3
- p85-sErbB3
- proto-oncogene-like protein c-ErbB-3
- receptor tyrosine-protein kinase erbB-3
- tyrosine kinase-type cell surface receptor HER3
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
- VSCN1
- NCBI_Gene: 2065
- UniProtKB: P21860
Human Predicted Functions
Enables several functions, including ErbB-3 class receptor binding activity; neuregulin binding activity; and protein heterodimerization activity. Involved in several processes, including extrinsic apoptotic signaling pathway in absence of ligand; phosphatidylinositol 3-kinase signaling; and positive regulation of protein tyrosine kinase activity. Located in basolateral plasma membrane and extracellular space. Part of ERBB3:ERBB2 complex. Implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Biomarker of carcinoma (multiple); ductal carcinoma in situ; prostate cancer; and urinary bladder cancer.
Mouse Erbb3 Target Information
- Target Symbol: Erbb3, erb-b2 receptor tyrosine kinase 3
- Alias:
- avian erythroblastosis oncogene B 3
- avian erythroblastosis oncogene B 3 receptor
- C76256
- Erbb-3
- Erbb3r
- expressed sequence C76256
- HER3
- nuc-ErbB3
- NCBI_Gene: 13867
Mouse Erbb3 Predicted Functions
Enables neuregulin receptor activity. Involved in ERBB2-ERBB3 signaling pathway; Schwann cell development; and myelination. Acts upstream of or within several processes, including negative regulation of motor neuron apoptotic process; nervous system development; and positive regulation of calcineurin-NFAT signaling cascade. Located in apical plasma membrane and lateral plasma membrane. Is active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ epithelium. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).
Rat Erbb3 Target Information
- Target Symbol: Erbb3, erb-b2 receptor tyrosine kinase 3
- Alias:
- avian erythroblastosis oncogene B 3
- c-erbB-3
- c-erbB3
- nuc-ErbB3
- proto-oncogene-like protein c-ErbB-3
- receptor tyrosine-protein kinase erbB-3
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- NCBI_Gene: 29496
- UniProtKB: Q62799
Rat Erbb3 Predicted Functions
Enables neuregulin binding activity and neuregulin receptor activity. Involved in several processes, including cellular response to mechanical stimulus; mammary gland involution; and positive regulation of D-glucose import. Located in neuronal cell body and postsynaptic membrane. Biomarker of amblyopia; chronic obstructive pulmonary disease; and median neuropathy. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).
