Powered by BiozHuman Her3/ErbB3 ELISA Kit
$299.00 – $419.00
ELISA Kit Detail Information
| Related Target | |
|---|---|
| Species | human |
| Sample Type | Serum, plasma, cell culture supernatant, and other biological samples |
| Sample Volume | 10 μL |
| Sensitivity | 2.11 pg/mL |
| Array Range | 93.75 - 6000 pg/mL |
| Assay Time | 3.5 h |
| Recovery | 82% - 102% |
| Average Recovery | 90% |
| Intra Precision | 2.3% - 5.1% |
| Inter Precision | 2.5% - 3.5% |
| Plate | Detachable 96-well plate |
| Storage | If the reagent kit is unopened, it should be stored at 4℃. However, if it has been opened, the standard solution should be stored at -20℃, while the other components should be stored at 4℃. |
| Delivery | 4℃ blue ice transportation |
| Components | ErbB3 Microplate ErbB3 Standard ErbB3 Detect Antibody Standard Diluent Assay Buffer Substrate Stop Solution Washing Buffer Plate Covers |
| Assay Principle | This kit utilizes a double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) technique. Specific anti-human ErbB3 antibodies are pre-coated on a high-affinity ELISA plate. Standard samples, test samples, and detection antibodies labeled with horseradish peroxidase (HRP) are added to the wells of the ELISA plate. After incubation, the ErbB3 present in the sample binds to the solid-phase antibody and the detection antibody. After washing, the TMB chromogenic substrate is added for color development while avoiding light. The intensity of the color reaction is directly proportional to the concentration of ErbB3 in the sample. The reaction is terminated by adding a stop solution, and the absorbance value is measured at a wavelength of 450 nm (with a reference wavelength range of 570-630 nm). |
Related Targets
ERBB3
ERBB3 Target Infomation Overview
- Target Symbol: ERBB3, erb-b2 receptor tyrosine kinase 3
- Gene Groups: Erb-b2 receptor tyrosine kinases
- Alias: LCCS2; HER3; HER-3
- Alias Names: lethal congenital contracture syndrome 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; human epidermal growth factor receptor 3
ERBB3, erb-b2 receptor tyrosine kinase 3 Target Infomation by Species
- Human
- Mouse
- Rat
Human ERBB3 Target Information
- Target Symbol: ERBB3, erb-b2 receptor tyrosine kinase 3
- Alias:
- avian erythroblastosis oncogene b 3
- c-erbB-3
- c-erbB3
- ErbB-3
- erbB3-S
- FERLK
- HER3
- human epidermal growth factor receptor 3
- LCCS2
- MDA-BF-1
- MGC88033
- p180-ErbB3
- p45-sErbB3
- p85-sErbB3
- proto-oncogene-like protein c-ErbB-3
- receptor tyrosine-protein kinase erbB-3
- tyrosine kinase-type cell surface receptor HER3
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
- VSCN1
- NCBI_Gene: 2065
- UniProtKB: P21860
Human Predicted Functions
Enables several functions, including ErbB-3 class receptor binding activity; neuregulin binding activity; and protein heterodimerization activity. Involved in several processes, including extrinsic apoptotic signaling pathway in absence of ligand; phosphatidylinositol 3-kinase signaling; and positive regulation of protein tyrosine kinase activity. Located in basolateral plasma membrane and extracellular space. Part of ERBB3:ERBB2 complex. Implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Biomarker of carcinoma (multiple); ductal carcinoma in situ; prostate cancer; and urinary bladder cancer.
Mouse Erbb3 Target Information
- Target Symbol: Erbb3, erb-b2 receptor tyrosine kinase 3
- Alias:
- avian erythroblastosis oncogene B 3
- avian erythroblastosis oncogene B 3 receptor
- C76256
- Erbb-3
- Erbb3r
- expressed sequence C76256
- HER3
- nuc-ErbB3
- NCBI_Gene: 13867
Mouse Erbb3 Predicted Functions
Enables neuregulin receptor activity. Involved in ERBB2-ERBB3 signaling pathway; Schwann cell development; and myelination. Acts upstream of or within several processes, including negative regulation of motor neuron apoptotic process; nervous system development; and positive regulation of calcineurin-NFAT signaling cascade. Located in apical plasma membrane and lateral plasma membrane. Is active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ epithelium. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).
Rat Erbb3 Target Information
- Target Symbol: Erbb3, erb-b2 receptor tyrosine kinase 3
- Alias:
- avian erythroblastosis oncogene B 3
- c-erbB-3
- c-erbB3
- nuc-ErbB3
- proto-oncogene-like protein c-ErbB-3
- receptor tyrosine-protein kinase erbB-3
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- NCBI_Gene: 29496
- UniProtKB: Q62799
Rat Erbb3 Predicted Functions
Enables neuregulin binding activity and neuregulin receptor activity. Involved in several processes, including cellular response to mechanical stimulus; mammary gland involution; and positive regulation of D-glucose import. Located in neuronal cell body and postsynaptic membrane. Biomarker of amblyopia; chronic obstructive pulmonary disease; and median neuropathy. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).
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