HGNC ID: 7097
Target Abstract:
Macrophage migration inhibitory factor (MIF) is an important regulator of innate immunity. Bacterial antigens stimulate white blood cells to release MIF into the bloodstream. Circulating MIF binds to CD74 on other immune cells to trigger an acute immune response, so MIF is an inflammatory cytokine. In addition, glucocorticoids can also stimulate white blood cells to release MIF. MIF regulates the function of macrophages in host defense by inhibiting the anti-inflammatory effects of glucocorticoids. MIF is an inflammatory mediator associated with the severity of rheumatoid arthritis. Plasma levels of MIF protein are elevated in people with schizophrenia, including in the early stages of the disease, but the clinical significance of this phenomenon has not been established. MIF also induces cardiac changes during sepsis. In addition, there is evidence that there is an association between MIF production and the metastatic potential of colon cancer.
MIF Target Infomation Overview
- Target Symbol: MIF, macrophage migration inhibitory factor
- Alias: GIF
- Previous Names: GLIF
- Alias Names: glycosylation-inhibiting factor; phenylpyruvate tautomerase; macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIF, macrophage migration inhibitory factor Target Infomation by Species
- Human
- Mouse
- Rat
Human MIF Target Information
- Target Symbol: MIF, macrophage migration inhibitory factor
- Alias:
- GIF
- GLIF
- L-dopachrome isomerase
- L-dopachrome tautomerase
- macrophage migration inhibitory factor (glycosylation-inhibiting factor)
- MMIF
- phenylpyruvate tautomerase
- NCBI_Gene: 4282
- UniProtKB: P14174
Human MIF Predicted Functions
Enables several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of protein phosphorylation; and regulation of intracellular signal transduction. Located in several cellular components, including cell surface; extracellular space; and nucleoplasm. Implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Biomarker of artery disease (multiple); asthma; lung disease (multiple); obesity; and rhinitis.
Mouse Mif Target Information
- Target Symbol: Mif, macrophage migration inhibitory factor (glycosylation-inhibiting factor)
- Alias:
- Glif
- glycosylation inhibiting factor
- NCBI_Gene: 17319
Mouse Mif Predicted Functions
Enables cytokine activity; phenylpyruvate tautomerase activity; and protease binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; cell aging; and regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor).
Rat Mif Target Information
- Target Symbol: Mif, macrophage migration inhibitory factor
- Alias:
- glutathione-binding 13 kDa protein
- L-dopachrome isomerase
- L-dopachrome tautomerase
- LOC103694877
- macrophage migration inhibitory factor (glycosylation-inhibiting factor)
- MGC72801
- phenylpyruvate tautomerase
- NCBI_Gene: 81683
Rat Mif Predicted Functions
Predicted to enable several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including positive regulation of transport; response to steroid hormone; and response to vitamin. Located in cytoplasm; extracellular space; and nucleus. Used to study several diseases, including acute necrotizing pancreatitis; cardiomyopathy (multiple); lung disease (multiple); retinitis; and toxic shock syndrome. Biomarker of borna disease; cystitis; kidney disease; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor).
